JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 QUICK SEARCH:   [advanced]


     


J Neurophysiol (January 3, 2007). doi:10.1152/jn.00977.2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
97/3/2254    most recent
00977.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Joelving, F. C
Right arrow Articles by Constantinidis, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Joelving, F. C
Right arrow Articles by Constantinidis, C.
Submitted on September 12, 2006
Accepted on December 28, 2006

Temporal properties of posterior parietal neuron discharges during working memory and passive viewing

Frederik C Joelving1, Albert Compte2, and Christos Constantinidis1*

1 Neurobiology & Anatomy, Wake Forest University, Winston-Salem, North Carolina, United States
2 Instituto de Neurociencias, Universidad Miguel Hernández, San Juan de Alicante, Spain

* To whom correspondence should be addressed. E-mail: cconstan{at}wfubmc.edu.

Working memory is mediated by the discharges of neurons in a distributed network of brain areas. Recently, it has been suggested that enhanced rhythmicity in neuronal activity may be critical for sustaining remembered information. In order to test whether working memory is characterized by unique temporal discharge patterns, we analyzed the autocorrelograms and power spectra of spike trains recorded from the posterior parietal cortex of monkeys performing a visuospatial working memory task. We compared the intervals of active memory maintenance and fixation and repeated the same analysis in spike trains from monkeys never trained to perform any kind of memory task. The most salient effect we observed was a decrease of power in the 5-10 Hz frequency range during the presentation of visual stimuli. This pattern was observed both in the working-memory condition and the control condition, although it was more prominent in the former, where it persisted after cue presentation when the monkeys actively remembered the stimulus' spatial location. Low-frequency power suppression resulted from relative refractory periods, which were significantly longer in the working-memory condition and presumably emerged from local-circuit inhibition. We also detected a spectral peak in the 15-20 Hz range, however this was more prominent during fixation than during the stimulus and working-memory periods. Our results are in line with previous reports in prefrontal cortex, and indicate that unique temporal patterns of single-neuron firing characterize persistent delay activity, however these do not involve the appearance of enhanced oscillations.




This article has been cited by other articles:


Home page
Cereb CortexHome page
T. Meyer, X.-L. Qi, and C. Constantinidis
Persistent Discharges in the Prefrontal Cortex of Monkeys Naive to Working Memory Tasks
Cereb Cortex, September 1, 2007; 17(suppl_1): i70 - i76.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2007 by the The American Physiological Society.