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J Neurophysiol (November 8, 2006). doi:10.1152/jn.00980.2006
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Submitted on September 13, 2006
Accepted on November 4, 2006

Glycine binding sites of presynaptic NMDA receptors may tonically regulate glutamate release in the rat visual cortex

Yan-Hai Li1 and Tai-Zhen Han1*

1 Department of Physiology, School of Medicine, Xi'an Jiaotong University, Xi'an, Shannxi, China

* To whom correspondence should be addressed. E-mail: htzhen{at}mail.xjtu.edu.cn.

In the central nervous system, activation of N-methyl- D-aspartate receptor (NMDA-R) glycine binding sites is a pre-requisite for activation of postsynaptic NMDA-Rs by the excitatory neurotransmitter glutamate. Here we provide electrophysiological evidence that the glycine binding sites of presynaptic NMDA-Rs regulate glutamate release in layer II/III pyramidal neurons of the rat visual cortex. Specifically, our results reveal that the frequency of miniature excitatory postsynaptic currents (mEPSCs) is significantly reduced by 7-chloro-kynurenic acid (7-Cl KYNA), a NMDA-R glycine binding site antagonist, and glycine or D-serine reverses this effect. Similar results are obtained when the open channel NMDA receptor blocker, MK-801, is included in the recording pipette. Our data indicate that the glycine binding site of postsynaptic NMDA-Rs is not saturated. Moreover, they suggest that presynaptic NMDA-Rs are located in layer II/III pyramidal neurons of the rat visual cortex, and that the glycine binding site of presynaptic NMDA-Rs tonically regulates glutamate release.




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