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J Neurophysiol (November 3, 2004). doi:10.1152/jn.00990.2004
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Submitted on September 21, 2004
Accepted on October 26, 2004

Pharmacological properties and functional role of a TRP-related ion channel in lobster olfactory receptor neurons

Yuriy V. Bobkov* and Barry W. Ache

* To whom correspondence should be addressed. E-mail: bobkov{at}whitney.ufl.edu.

Odors activate lobster olfactory receptor neurons (ORNs) through phosphoinositide signaling that appears to target a Na+-gated non-selective cation channel (Zhainazarov et al. 1998). The Na+-gated channel is a potential member of the growing family of transient receptor potential (TRP) channels. Here, we test the effect of potential antagonists on the channel in cell-free patches from cultured lobster ORNs. We show that the channel is antagonized by H+ and the TRP channel blockers 2-aminoethoxydiphenyl borate (2-APB), SKF96365, ruthenium red, Al3+, Gd3+, and La3+. We then use this enhanced antagonist profile together with the agonists Na+ and Ca2+ to implicate the channel in signal amplification in the cells.




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