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* To whom correspondence should be addressed. E-mail: mjmustar{at}rmy.emory.edu.
The dorsolateral pontine nucleus (DLPN) and nucleus reticularis tegmenti pontis (NRTP) are basilar pontine nuclei important for control of eye movements. The aim of this study was to compare the response properties of neurons in DLPN and rostral NRTP (rNRTP) during visual, oculomotor and vestibular testing. We tested 51 DLPN neurons that were modulated during smooth pursuit (23/51) or during motion of a large-field visual stimulus (28/51). Following vestibular testing, we found that the majority of smooth pursuit related neurons in DLPN were best classified as gaze (13/23) or eye velocity (7/23) related. Only a small percentage (3/51) of DLPN neurons responded during VOR in the dark (VORd). We tested rNRTP neurons as described above and found the majority of neurons (35/43) were modulated during smooth pursuit or during motion of a large-field stimulus only (4/43). A significant proportion of our rNRTP gaze-velocity neurons (10/18) were also modulated during VORd. We found that the majority of smooth pursuit related neurons in rNRTP were best classified as gaze velocity (18/35) or gaze acceleration (11/35) sensitive. The remaining neurons were classified as eye position or eye/head related. We used multiple linear-regression modeling to determine the relative contributions of eye, head and visual inputs to the responses of DLPN and rNRTP neurons. Our results support the suggestion that both DLPN and rNRTP play significant roles not only in control of smooth pursuit but also in control of gaze.
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S. Ono and M. J. Mustari Extraretinal Signals in MSTd Neurons Related to Volitional Smooth Pursuit J Neurophysiol, November 1, 2006; 96(5): 2819 - 2825. [Abstract] [Full Text] [PDF]
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C. M. Stewart, M. J. Mustari, and A. A. Perachio Visual-Vestibular Interactions During Vestibular Compensation: Role of the Pretectal NOT in Horizontal VOR Recovery After Hemilabyrinthectomy in Rhesus Monkey J Neurophysiol, October 1, 2005; 94(4): 2653 - 2666. [Abstract] [Full Text] [PDF]
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S. Ono, V. E. Das, J. R. Economides, and M. J. Mustari Modeling of Smooth Pursuit-Related Neuronal Responses in the DLPN and NRTP of the Rhesus Macaque J Neurophysiol, January 1, 2005; 93(1): 108 - 116. [Abstract] [Full Text] [PDF]
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