JN Miami Valley Hospital
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Neurophysiol (November 17, 2004). doi:10.1152/jn.01017.2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
93/4/2012    most recent
01017.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lee, J. C.
Right arrow Articles by Foehring, R. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, J. C.
Right arrow Articles by Foehring, R. C.
Submitted on September 27, 2004
Accepted on November 15, 2004

The Effects of Temperature on Calcium transients and Ca2+-dependent Afterhyperpolarizations in Neocortical Pyramidal Neurons

Jonathan C. Lee1, Joseph C. Callaway1, and Robert C. Foehring1*

1 Anatomy and Neurobiology, University of Tennessee, Memphis, TN, USA

* To whom correspondence should be addressed. E-mail: rfoehrin{at}utmem.edu.

In neocortical pyramidal neurons, the medium (mAHP) and slow AHP (sAHP) have different relationships with intracellular [Ca2+] (Abel et al. 2004). To further explore these differences, we varied bath temperature and compared passive and active membrane properties and Ca2+ transients in response to a single action potential (AP), or trains of APs. We tested whether (i) Ca2+-dependent events are more temperature-sensitive than voltage-dependent ones, (ii) the slow rise time of the sAHP is limited by diffusion, and (iii) temperature sensitivity differs between the mAHP and sAHP. We found that the decay time course of Ca2+ transients was also very temperature sensitive. In contrast, the mAHP (amplitude, time-to-peak and exponential decay) and sAHP peak amplitude were moderately sensitive to temperature. The amplitudes of intracellular Ca2+ transients evoked either by a single spike or a train of spikes showed modest temperature sensitivities. Pyramidal neuron input resistance was increased by cooling. With the exception of threshold, which remained unchanged between 22°-35°C, action potential parameters (amplitude, half-width, maximum rates of rise and fall) were modestly affected by temperature. Collectively, these data suggest that (i) temperature sensitivity was higher for the Ca2+-dependent sAHP than for voltage-dependent AP parameters or for the mAHP, and (ii) diffusion of Ca2+ over distance cannot explain the slow rise of the sAHP in these cells.




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
B. A. Graham, A. M. Brichta, and R. J. Callister
Recording Temperature Affects the Excitability of Mouse Superficial Dorsal Horn Neurons, In Vitro
J Neurophysiol, May 1, 2008; 99(5): 2048 - 2059.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. R. Young, R. Bianchi, and R. K. S. Wong
Signaling Mechanisms Underlying Group I mGluR-Induced Persistent AHP Suppression in CA3 Hippocampal Neurons
J Neurophysiol, March 1, 2008; 99(3): 1105 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. M. Wilson, A. I. Cowan, and R. M. Brownstone
Hb9 Interneurons: Reply to Ziskind-Conhaim and Hinckley
J Neurophysiol, February 1, 2008; 99(2): 1047 - 1049.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Teagarden, J. F. Atherton, M. D. Bevan, and C. J. Wilson
Accumulation of cytoplasmic calcium, but not apamin-sensitive afterhyperpolarization current, during high frequency firing in rat subthalamic nucleus cells
J. Physiol., February 1, 2008; 586(3): 817 - 833.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Diaz-Quesada and M. Maravall
Intrinsic Mechanisms for Adaptive Gain Rescaling in Barrel Cortex
J. Neurosci., January 16, 2008; 28(3): 696 - 710.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Fernandez de Sevilla, M. Fuenzalida, A. B. Porto Pazos, and W. Buno
Selective Shunting of the NMDA EPSP Component by the Slow Afterhyperpolarization in Rat CA1 Pyramidal Neurons
J Neurophysiol, May 1, 2007; 97(5): 3242 - 3255.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Kelly and J. Church
Relationships Between Calcium and pH in the Regulation of the Slow Afterhyperpolarization in Cultured Rat Hippocampal Neurons
J Neurophysiol, November 1, 2006; 96(5): 2342 - 2353.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. J. Wilson and J. A. Goldberg
Origin of the Slow Afterhyperpolarization and Slow Rhythmic Bursting in Striatal Cholinergic Interneurons
J Neurophysiol, January 1, 2006; 95(1): 196 - 204.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Guatteo, K. K. H. Chung, T. K. Bowala, G. Bernardi, N. B. Mercuri, and J. Lipski
Temperature Sensitivity of Dopaminergic Neurons of the Substantia Nigra Pars Compacta: Involvement of Transient Receptor Potential Channels
J Neurophysiol, November 1, 2005; 94(5): 3069 - 3080.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2004 by the The American Physiological Society.