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J Neurophysiol (February 16, 2005). doi:10.1152/jn.01027.2004
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Submitted on September 29, 2004
Accepted on February 11, 2005

Background synaptic conductance and Precision of EPSP-Spike Coupling at Pyramidal Cells

Veronika Zsiros1 and Shaul Hestrin1*

1 Comparative Medicine, Stanford University School of Medicine, Stanford, CA, USA

* To whom correspondence should be addressed. E-mail: shaul.hestrin{at}stanford.edu.

The temporal precision of converting EPSPs into spikes at pyramidal cells is critical for the coding of information in the cortex. Several in vitro studies have shown that voltage-dependent conductances in pyramidal cells can prolong the EPSP time course resulting in an imprecise EPSP-spike coupling. We have used dynamic clamp techniques to mimic the in vivo background synaptic conductance in cortical slices and investigated how the ongoing synaptic activity may affect the EPSP time course near threshold and the EPSP spike coupling. We report here that background synaptic conductance dramatically diminished the depolarization related prolongation of the EPSPs in pyramidal cells and improved the precision of spike timing. Furthermore, we found that background synaptic conductance can affect the interaction among action potentials in a spike train. Thus, the level of ongoing synaptic activity in the cortex may regulate the capacity of pyramidal cells to process temporal information.




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