| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, MA, USA
* To whom correspondence should be addressed. E-mail: turrigiano{at}brandeis.edu.
Neuronal excitability has a large impact on network behavior, and plasticity in intrinsic excitability could serve as an important information storage mechanism. Here we ask whether postsynaptic excitability of layer V pyramidal neurons from primary visual cortex can be rapidly regulated by activity. Whole-cell current clamp recordings were obtained from visual cortical slices and intrinsic excitability was measured by recording the firing response to small depolarizing test pulses. Inducing neurons to fire at high frequency (30-40 Hz) in bursts for 5 minutes in the presence of synaptic blockers increased the firing rate evoked by the test pulse. This long-term potentiation of intrinsic excitability (LTP-IE) lasted for as long as we held the recording (>60 min). LTP-IE was accompanied by a leftward shift in the entire frequency vs. current (FI) curve and a decrease in threshold current and voltage. Passive neuronal properties were unaffected by the induction protocol, indicating that LTP-IE occurred through modification in voltage-gated conductances. Reducing extracellular calcium during the induction protocol, or buffering intracellular calcium with BAPTA, prevented LTP-IE. Finally, blocking PKA activation prevented, while pharmacological activation of PKA both mimicked and occluded, LTP-IE. This suggests that LTP-IE occurs through postsynaptic calcium influx and subsequent activation of PKA. Activity-dependent plasticity in intrinsic excitability could greatly expand the computational power of individual neurons.
This article has been cited by other articles:
|
|
 |
|
  Q.-Q. Sun Experience-Dependent Intrinsic Plasticity in Interneurons of Barrel Cortex Layer IV J Neurophysiol, November 1, 2009; 102(5): 2955 - 2973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Fink and T. J. O'Dell Short Trains of Theta Frequency Stimulation Enhance CA1 Pyramidal Neuron Excitability in the Absence of Synaptic Potentiation J. Neurosci., September 9, 2009; 29(36): 11203 - 11214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Debanne Plasticity of neuronal excitability in vivo J. Physiol., July 1, 2009; 587(13): 3057 - 3058. [Full Text] [PDF]
|
|
|
|
|
|
J. T. Paz, Sév. Mahon, P. Tiret, S.ép. Genet, B. Delord, and S.ép. Charpier Multiple forms of activity-dependent intrinsic plasticity in layer V cortical neurones in vivo J. Physiol., July 1, 2009; 587(13): 3189 - 3205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Francesconi, F. Berton, V. Repunte-Canonigo, K. Hagihara, D. Thurbon, D. Lekic, S. E. Specio, T. N. Greenwell, S. A. Chen, K. C. Rice, et al. Protracted Withdrawal from Alcohol and Drugs of Abuse Impairs Long-Term Potentiation of Intrinsic Excitability in the Juxtacapsular Bed Nucleus of the Stria Terminalis J. Neurosci., April 29, 2009; 29(17): 5389 - 5401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Izquierdo, I. Harvey, and R. D. Beer Associative Learning on a Continuum in Evolved Dynamical Neural Networks Adaptive Behavior, December 1, 2008; 16(6): 361 - 384. [Abstract] [PDF]
|
|
|
|
|
|
W. W. Wu, C. S. Chan, D. J. Surmeier, and J. F. Disterhoft Coupling of L-Type Ca2+ Channels to KV7/KCNQ Channels Creates a Novel, Activity-Dependent, Homeostatic Intrinsic Plasticity J Neurophysiol, October 1, 2008; 100(4): 1897 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser Dendritic Excitability and Synaptic Plasticity Physiol Rev, April 1, 2008; 88(2): 769 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Campanac and D. Debanne Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons J. Physiol., February 1, 2008; 586(3): 779 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Brager and D. Johnston Plasticity of Intrinsic Excitability during Long-Term Depression Is Mediated through mGluR-Dependent Changes in Ih in Hippocampal CA1 Pyramidal Neurons J. Neurosci., December 19, 2007; 27(51): 13926 - 13937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, J. D. Bohanick, M. Nishihara, J. K. Seamans, and C. R. Yang Dopamine D1/5 Receptor-Mediated Long-Term Potentiation of Intrinsic Excitability in Rat Prefrontal Cortical Neurons: Ca2+-Dependent Intracellular Signaling J Neurophysiol, March 1, 2007; 97(3): 2448 - 2464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Kaczorowski, J. Disterhoft, and N. Spruston Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions J. Physiol., February 1, 2007; 578(3): 799 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Schulz Plasticity and stability in neuronal output via changes in intrinsic excitability: it's what's inside that counts J. Exp. Biol., December 15, 2006; 209(24): 4821 - 4827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Haedo and J. Golowasch Ionic Mechanism Underlying Recovery of Rhythmic Activity in Adult Isolated Neurons J Neurophysiol, October 1, 2006; 96(4): 1860 - 1876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Desai, T. M. Casimiro, S. M. Gruber, and P. W. Vanderklish Early Postnatal Plasticity in Neocortex of Fmr1 Knockout Mice J Neurophysiol, October 1, 2006; 96(4): 1734 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Desai and E. C. Walcott Synaptic bombardment modulates muscarinic effects in forelimb motor cortex. J. Neurosci., February 22, 2006; 26(8): 2215 - 2226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Burrell and C. L. Sahley Serotonin Mediates Learning-Induced Potentiation of Excitability J Neurophysiol, December 1, 2005; 94(6): 4002 - 4010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xu, N. Kang, L. Jiang, M. Nedergaard, and J. Kang Activity-Dependent Long-Term Potentiation of Intrinsic Excitability in Hippocampal CA1 Pyramidal Neurons J. Neurosci., February 16, 2005; 25(7): 1750 - 1760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hadjilambreva, E. Mix, A. Rolfs, J. Muller, and U. Strauss Neuromodulation by a Cytokine: Interferon-{beta} Differentially Augments Neocortical Neuronal Activity and Excitability J Neurophysiol, February 1, 2005; 93(2): 843 - 852. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
