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J Neurophysiol (March 26, 2003). doi:10.1152/jn.01084.2002
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Submitted on December 3, 2002
Accepted on February 15, 2003

Glutamatergic and GABAergic Regulation of Neural Responses in Inferior Colliculus to Amplitude Modulated Sounds

Huiming Zhang1 and Jack B Kelly1*

1 Psychology Department, Laboratory of Sensory Neuroscience, Carleton University, Ottawa, Ontario, Canada

* To whom correspondence should be addressed. E-mail: jkelly{at}ccs.carleton.ca.

Recordings were made from single neurons in the rat inferior colliculus in response to sinusoidally amplitude modulated sounds (10 sec duration) presented to the contralateral ear. Neural responses were determined for different rates of modulation (0.5 Hz to 1 kHz) at a depth of 100 % and modulation transfer functions were generated based on firing rate (MTFFR) and vector strength (MTFVS). The effects of AMPA, NMDA and GABAA receptor antagonists were examined by releasing drugs iontophoretically through a multi-barrel pipette attached to a single barrel recording pipette. Both the AMPA receptor antagonist, NBQX, and the NMDA receptor antagonist, CPP, resulted in a decrease in firing rate and the GABAA receptor antagonist, bicuculline, produced an increase in the firing rate in most of the cells examined. In some cases the shape of the MTFFR was modified slightly by receptor antagonists, but in most cases the peak firing rate that determined a neuron's best modulation frequency remained the same. Also, there were no changes during delivery of either excitatory or inhibitory antagonists in the maximum response synchrony at the peak of the MTFVS although some changes were noticed at off-peak modulation rates particularly with the AMPA receptor antagonist, NBQX.




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