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J Neurophysiol (December 1, 2004). doi:10.1152/jn.01091.2004
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Submitted on October 18, 2004
Accepted on November 30, 2004

Development Of An Inhibitory Interneuronal Circuit In The Embryonic Spinal Cord

Huaying Xu1, Patrick J. Whelan2, and Peter A. Wenner1*

1 Department of Physiology, Emory University, School of Medicine, Atlanta, GA, USA
2 Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada

* To whom correspondence should be addressed. E-mail: pwenner{at}emory.edu.

Locally projecting inhibitory interneurons play a crucial role in the patterning and timing of network activity. However, because of their relative inaccessibility, little is known about their development or incorporation into circuits. In this study we characterized the functional onset, neurotransmitters, rostrocaudal spread, and funicular distribution of one such spinal interneuronal circuit during development. The R-interneuron is the avian homologue of the mammalian Renshaw cell. Both cell types receive input from motoneuron recurrent collaterals, and make direct connections back onto motoneurons. By stimulating motoneurons projecting in a given ventral root and recording the response in adjacent ventral roots, we demonstrate that the R-interneuron circuit becomes functional between embryonic day 6 (E6) and E7. This ventral root response is observed at E11, and at E14 until it can no longer be detected at E16. Using bath applied neurotransmitter receptor antagonists we were able to demonstrate that the circuit is predominately nicotinic and GABAergic from E7.5 to E15. We also found a glutamatergic component to the pathway throughout this developmental period. The R-interneuron projects 3 or more segments both rostrally and caudally through the ventrolateral funiculus. The distribution of this circuit may become more locally focused between E7.5 and E15.




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