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1 Sobell Department of Motor Neuroscience and Movement Disorders,, Institute of Neurology, UCL, London, United Kingdom; Dipartimento di Neuroscienze, Sezione di Fisiologia, Università di Parma, Parma, Italy
2 Sobell Department of Motor Neuroscience and Movement Disorders,, Institute of Neurology, UCL, London, United Kingdom
* To whom correspondence should be addressed. E-mail: brochier{at}incm.cnrs-mrs.fr.
To understand the relative contributions of primary motor cortex (M1) and area F5 of the ventral premotor cortex (PMv) to visually-guided grasp, we made simultaneous multiple electrode recordings from the hand representations of these two areas in two adult macaque monkeys. The monkeys were trained to fixate, reach out and grasp one of 6 objects presented in a pseudorandom order. 326 task-related M1 neurons, 104 of which were identified as pyramidal tract neurons, and 138 F5 neurons were analysed as separated populations. All three populations showed activity that distinguished the six objects grasped by the monkey. These 3 populations respond in a manner that generalises across different sets of objects. F5 neurons showed object/grasp related tuning earlier than M1 neurons in the visual presentation and pre-movement periods. Also, F5 neurons generally showed a greater preference for particular objects/grasps than did M1 neurons. F5 neurons generally remained tuned to a particular grasp throughout both the pre-movement and reach-to-grasp phases of the task, while M1 neurons show different selectivity during the different phases. We also found that different types of grasp appear to be represented by different overall levels of activity within the F5-M1 circuit. Altogether, these properties are consistent with the notion that F5 grasping-related neurons play a role in translating visual information about the physical properties of an object into the motor commands that are appropriate for grasping, and which are elaborated within M1 for delivery to the appropriate spinal machinery controlling hand and digit muscles.
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