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J Neurophysiol (April 25, 2007). doi:10.1152/jn.01104.2006
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Submitted on October 16, 2006
Accepted on April 17, 2007

Subthalamic stimulation and neuronal activity in the substantia nigra in Parkinson's disease

David Maltete1, Nicolas Jodoin2, Carine Karachi3, Jean-Luc Houeto4, Soledad Navarro5, Philippe Cornu5, Yves Agid2, and Marie-Laure Welter2*

1 CIC-INSERMU679/Fédération des Maladies du Système Nerveux, Groupe Hospitalier Pitié-Salpêtrière-APHP, PARIS, France; Service de Neurologie, CHU Rouen, ROUEN, France
2 CIC-INSERMU679/Fédération des Maladies du Système Nerveux, Groupe Hospitalier Pitié-Salpêtrière-APHP, PARIS, France
3 INSERM U679, Service de Neurochirurgie, Groupe Hospitalier Pitié-Salpêtrière-APHP, Paris, France
4 Service de Neurologie, CHU Poitiers, PARIS, France; CIC-INSERMU679/Fédération des Maladies du Système Nerveux, Groupe Hospitalier Pitié-Salpêtrière-APHP, PARIS, France
5 Service de Neurochirurgie, Groupe Hospitalier Pitié-Salpêtrière, PARIS, France

* To whom correspondence should be addressed. E-mail: marie-laure.welter{at}psl.aphp.fr.

High frequency stimulation of the subthalamic (STN) nucleus is an effective treatment for severe forms of Parkinson's disease (PD). To study the effects of high-frequency STN stimulation on one of the main output pathways of the basal ganglia, single-unit recordings of the neuronal activity of the substantia nigra pars reticulata (SNr) were performed before, during and after the application of STN electrical stimulation in 8 PD patients. During STN stimulation at 14-Hz, no change in either the mean firing rate or the discharge pattern of SNr neurons was observed. STN stimulation at 140-Hz decreased the mean firing rate by 64% and the mean duration of bursting mode activity of SNr neurons by 70%. The SNr residual neuronal activity during 140-Hz STN stimulation was driven by the STN stimulation. How the decrease in rate and modification of firing pattern with evoked neuronal activity of SNr neurons during high frequency STN stimulation contribute to the improvement of Parkinsonian motor disability remains to be elucidated.




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