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J Neurophysiol (February 23, 2005). doi:10.1152/jn.01125.2004
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Submitted on November 1, 2004
Accepted on February 16, 2005

Activation of Nucleus Basalis Facilitates Cortical Control of a Brainstem Motor Program

Rune W. Berg1, Beth Friedman1, Lee F. Schroeder1, and David Kleinfeld1*

1 Physics, UCSD, La Jolla, CA, USA

* To whom correspondence should be addressed. E-mail: dk{at}physics.ucsd.edu.

We test the hypothesis that activation of nucleus basalis magnocellularis (NBM), which provides cholinergic input to cortex, facilitates motor control. Our measure of facilitation are changes in the direction and time-course of vibrissa movements that are elicited by microstimulation of vibrissa motor (M1) cortex. In particular, microstimulation leads solely to a transient retraction of the vibrissae in the sessile animal but to a full motion sequence of protraction followed by retraction in the aroused animal. We observe that activation of NBM, as assayed by cortical desynchronization, induces a transition from microstimulation-evoked retraction to full sweep sequences. This dramatic change in the vibrissa response to microstimulation is blocked by systemic delivery of atropine and, in anesthetized animals, an analogous change is blocked by the topical administration of atropine to M1 cortex. We conclude that NBM significantly facilitates the ability of M1 cortex to control movements. Our results bear on the importance of cholinergic activation in schemes for neuroprosthetic control of movement.




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