Long term potentiation of human pain perception (nociceptive LTP) to single electrical test stimuli was induced by high frequency stimulation (HFS) of cutaneous nociceptive afferents. Numerical pain ratings and a list of sensory pain descriptors disclosed the same magnitude of nociceptive LTP (23 % increase for >60 min, p<0.001), whereas affective pain descriptors were not significantly enhanced. Factor analysis of the sensory pain descriptors showed that facilitation was restricted to two factors characterized by hot and burning (+41 %) and piercing and stinging (+21 %, both p<0.01), whereas a factor represented by throbbing and beating was not significantly increased (+9 %, p=0.47). The increased perception of the burning pain quality for more than one hour after HFS is interpreted as a LTP-like facilitation of the conditioned cutaneous C-fiber pathway. Additionally, the increase of the stinging pain quality supplied evidence for facilitation of a sharpness-sensitive A-fiber pathway.