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J Neurophysiol (May 9, 2007). doi:10.1152/jn.01141.2006
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Submitted on October 26, 2006
Accepted on May 6, 2007

Population Activity in the Human Dorsal Pathway Predicts the Accuracy of Visual Motion Detection

Tobias Hinrich Donner1*, Markus Siegel2, Robert Oostenveld3, Pascal Fries4, Markus Bauer4, and Andreas K. Engel5

1 Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; F.C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, Netherlands; Center for Neural Science and Department of Psychology, New York University, New York, New York, United States
2 Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; F.C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, Netherlands
3 F.C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, Netherlands
4 F.C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, Netherlands; Department of Biophysics, Radboud University Nijmegen, Nijmegen, Netherlands
5 Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

* To whom correspondence should be addressed. E-mail: tobias{at}cns.nyu.edu.

A person's ability to detect a weak visual target stimulus varies from one viewing to the next. We tested if the trial-to-trial fluctuations of neural population activity in the human brain are related to the fluctuations of behavioral performance in a 'yes-no' visual motion detection task. We recorded neural population activity with whole-head magnetoencephalography (MEG) while subjects searched for a weak coherent motion signal embedded in spatiotemporal noise. We found that, during motion viewing, MEG activity in the 12-24 Hz ('beta') frequency range is higher, on average, before correct behavioral choices than before errors, and that it predicts correct choices on a trial-by-trial basis. This performance-predictive activity is not evident in the pre-stimulus baseline and builds up slowly after stimulus onset. Source reconstruction revealed that the performance-predictive activity is expressed in the posterior parietal and dorsolateral prefrontal cortices, and, less strongly, in the visual motion-sensitive area MT+. 12-24 Hz activity in these key stages of the human dorsal visual pathway is correlated with behavioral choice in both, target present and absent conditions. Importantly, in the absence of the target, 12-24 Hz activity tends to be higher before 'no' choices ('correct rejects') than before 'yes' choices ('false alarms'). It thus predicts the accuracy, and not the content, of subjects' upcoming perceptual reports. We conclude that beta band activity in the human dorsal visual pathway indexes, and potentially controls, the efficiency of neural computations underlying simple perceptual decisions.




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