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J Neurophysiol (December 7, 2005). doi:10.1152/jn.01149.2005
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Submitted on November 1, 2005
Accepted on December 6, 2005

Interactions between asynchronous release and short-term plasticity in the nucleus accumbens slice

Gregory O. Hjelmstad1*

1 Department of Neurology, Wheeler Center for the Neurobiology of Addiction and the Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA, USA

* To whom correspondence should be addressed. E-mail: gregh{at}egcrc.net.

Glutamate synapses in the nucleus accumbens (NAc) display asynchronous release in response to trains of stimulation. However, it is unclear what role this asynchronous release plays in synaptic transmission in this nucleus. This process was investigated, specifically looking at the interaction between short-term depression and asynchronous release. These results indicate that synchronous and asynchronous release do not compete for a depleted readily-releasable pool of vesicles.







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