JN Miami Valley Hospital
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 QUICK SEARCH:   [advanced]


     


J Neurophysiol (March 1, 2006). doi:10.1152/jn.01155.2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
95/6/3742    most recent
01155.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Campbell, R. A. A.
Right arrow Articles by King, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Campbell, R. A. A.
Right arrow Articles by King, A. J.
Submitted on November 1, 2005
Accepted on February 24, 2006

Binaural Level Functions in Ferret Auditory Cortex: Evidence for a Continuous Distribution of Response Properties

Robert A. A. Campbell1, Jan W. H. Schnupp1, Akhil Shial1, and Andrew J. King1*

1 Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom

* To whom correspondence should be addressed. E-mail: ajk{at}physiol.ox.ac.uk.

Many previous studies have subdivided auditory neurons into a number of physiological classes according to various criteria applied to their binaural response properties. However, it is often unclear whether such classifications represent discrete classes of neurons, or whether they merely reflect a potentially convenient but ultimately arbitrary partitioning of a continuous underlying distribution of response properties. In this study we recorded the binaural response properties of 310 units in the auditory cortex of anesthetized ferrets, using an extensive range of interaural level differences (ILDs) and average binaural levels (ABLs). Most recordings were from primary auditory fields on the middle ectosylvian gyrus and from neurons with characteristic frequencies >5 kHz. We used simple multivariate statistics to quantify a fundamental coding feature: the shapes of the binaural response functions. The shapes of all 310 binaural response surfaces were represented as points in a 5-dimensional principal component space. This space captured the underlying shape of all the binaural response surfaces. The distribution of binaural level functions was not homogenous as some shapes were more common than others. Despite this, clustering validation techniques revealed no evidence for the existence of discrete, or partially overlapping, clusters that could serve as a basis for an objective classification of binaural level functions. We also examined the gradients of the response functions for the population of units; these gradients were greatest near the midline, which is consistent with free-field data showing that cortical neurons are most sensitive to changes in stimulus location in this region of space.




This article has been cited by other articles:


Home page
J. Neurophysiol.Home page
I. Nelken, J. K. Bizley, F. R. Nodal, B. Ahmed, A. J. King, and J. W. H. Schnupp
Responses of Auditory Cortex to Complex Stimuli: Functional Organization Revealed Using Intrinsic Optical Signals
J Neurophysiol, April 1, 2008; 99(4): 1928 - 1941.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
J. K. Bizley, F. R. Nodal, C. H. Parsons, and A. J. King
Role of Auditory Cortex in Sound Localization in the Midsagittal Plane
J Neurophysiol, September 1, 2007; 98(3): 1763 - 1774.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
B. Gourevitch and J. J. Eggermont
Spatial Representation of Neural Responses to Natural and Altered Conspecific Vocalizations in Cat Auditory Cortex
J Neurophysiol, January 1, 2007; 97(1): 144 - 158.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2006 by the The American Physiological Society.