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J Neurophysiol (May 26, 2004). doi:10.1152/jn.01181.2003
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Submitted on December 8, 2003
Accepted on May 10, 2004

The modulation of locomotor activity by multiple 5-HT and dopaminergic receptor subtypes in the neonatal mouse spinal cord

Michelle A. Madriaga1, Lisa C. McPhee1, Taha Chersa1, Kimberly J. Christie1, and Patrick J. Whelan1*

1 Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada

* To whom correspondence should be addressed. E-mail: whelan{at}ucalgary.ca.

Recently, it has been demonstrated that bath-applied 5-HT can elicit fictive locomotion from perinatal mouse preparations. Since 5-HT acts on multiple receptor subtypes, the focus of this study was to examine which receptor families contribute to the genesis and modulation of locomotor activity. Blockade of 5-HT2 (ketanserin or N-desmethylclozapine) or 5-HT7 receptors (SB-269970) could reversibly block or modulate the locomotor-like pattern. A 5-HT2 agonist ({alpha}-methyl-5-HT) was shown to be capable of activating the rhythm. Bath application of 5-HT7 agonists (5-CT) generally led to a tonic increase in neurogram discharge, accompanied by bouts of rhythmic activity. Blockade of dopaminergic receptors (D1 (SCH-23390 or LE 300) / D2 ((±-sulpiride or L-741,626) could reversibly disrupt the rhythm and most effectively did so when the D1 and D2 antagonists were added together. Conversely, 5-HT2 and D1/D2 agonists can interact to evoke locomotor activity. Overall, our data show that in the neonatal mouse preparation, 5-HT evoked locomotion partly depends on 5-HT2, 5-HT7 and dopaminergic receptor subtypes.




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