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J Neurophysiol (February 23, 2005). doi:10.1152/jn.01200.2004
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Submitted on November 22, 2004
Accepted on February 21, 2005

Distinct Roles for Lateral and Medial Anterior Prefrontal Cortex in Contextual Recollection

Jon S. Simons1*, Sam J. Gilbert1, Adrian M. Owen1, Paul C. Fletcher1, and Paul W. Burgess1

1 Institute of Cognitive Neuroscience, University College London, London, United Kingdom

* To whom correspondence should be addressed. E-mail: jon.simons{at}ucl.ac.uk.

A key feature of human recollection is the ability to remember details of the context in which events were experienced as well as details of the events themselves. Previous studies have implicated a number of regions of prefrontal cortex in contextual recollection, but the role of anterior prefrontal cortex has so far resisted detailed characterization. We used event-related fMRI to contrast recollection of two forms of contextual information: (a) decisions one had previously made about stimuli ("task memory"), and (b) which of two temporally-distinct lists those stimuli had been presented in ("list memory"). In addition, a retrieval cue manipulation permitted evaluation of the stage of the retrieval process in which the activated regions might be involved. The results indicated that anterior prefrontal cortex responded significantly more during recollection of task than list context details. Furthermore, activation profiles for lateral and medial aspects of anterior prefrontal cortex suggested differing roles in recollection. Lateral regions appear to be more involved in the early retrieval specification stages of recollection, with medial regions contributing to later stages (e.g., monitoring and verification).




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