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J Neurophysiol (January 30, 2008). doi:10.1152/jn.01204.2007
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Submitted on October 29, 2007
Accepted on January 25, 2008

N-arachidonoyl L-serine, a putative endocannabinoid, alters the activation of N-type Ca2+ channels in sympathetic neurons

Juan Guo1, Damian J Williams1, and Stephen R. Ikeda2*

1 Lab. Molecular Physiology, NIH/NIAAA, Bethesda, Maryland, United States
2 Lab. Molecular Physiology, NIH/NIAAA, Bethesda, Maryland, United States; , United States

* To whom correspondence should be addressed. E-mail: sikeda{at}mail.nih.gov.

The effect of N-arachidonoyl L-serine (ARA-S), a recently discovered lipoamino acid found in the central nervous system, on N-type calcium channels of rat sympathetic ganglion neurons was determined using whole-cell patch-clamp. Application of ARA-S produced a rapid and reversible augmentation of calcium current that was voltage-dependent and resulted from a hyperpolarizing shift in the activation curve. ARA-S did not influence G-protein modulation of calcium channels and appeared to act independently of G-protein coupled receptors. These findings provide a foundation for investigating possible roles for ARA-S in nervous system function.




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