JN AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Neurophysiol (February 6, 2008). doi:10.1152/jn.01210.2007
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
99/4/2026    most recent
01210.2007v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wu, L.-J.
Right arrow Articles by Zhuo, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wu, L.-J.
Right arrow Articles by Zhuo, M.
Submitted on October 30, 2007
Accepted on February 4, 2008

Resting Microglial Motility is Independent of Synaptic Plasticity in Mammalian Brain

Long-Jun Wu1 and Min Zhuo2*

1 Physiology, University of Toronto, Toronto, Canada
2 Physiology, Univ of Toronto, Toronto, Canada

* To whom correspondence should be addressed. E-mail: min.zhuo{at}utoronto.ca.

Microglia are well-known for their roles in brain injuries and infections. However, there is no function attributes to resting microglia so far. Here we performed a combination of simultaneous electrophysiology and time-lapse confocal imaging in GFP-labeled microglia in acute hippocampal slices. In contrast to CA1 neurons, microglia showed no spontaneous or evoked synaptic currents. Neither glutamate nor GABA-induced current/chemotaxis of microglia was detected. Strong tetanic stimulation of Schaffer-collateral pathways that induces CA1 LTP did not affect microglial motilities. Our results suggest that microglia is highly reserved for neuronal protective function but not synaptic plasticity in the brain.




This article has been cited by other articles:


Home page
 IOVSHome page
K. J. Liang, J. E. Lee, Y. D. Wang, W. Ma, A. M. Fontainhas, R. N. Fariss, and W. T. Wong
Regulation of Dynamic Behavior of Retinal Microglia by CX3CR1 Signaling
Invest. Ophthalmol. Vis. Sci., September 1, 2009; 50(9): 4444 - 4451.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2008 by the The American Physiological Society.