JN AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Neurophysiol (September 1, 2004). doi:10.1152/jn.01213.2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
93/3/1659    most recent
01213.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bradley, D. C.
Right arrow Articles by Xu, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bradley, D. C.
Right arrow Articles by Xu, H.
Submitted on December 15, 2003
Accepted on August 19, 2004

VISUOTOPIC MAPPING THROUGH A MULTICHANNEL STIMULATING IMPLANT IN PRIMATE V1

David C. Bradley*, Philip R. Troyk, Joshua A. Berg, Martin Bak, Stuart Cogan, Robert Erickson, Conrad Kufta1, Massimo Mascaro, Douglas McCreery, Edward M. Schmidt1, Vernon Towle, and Hong Xu

1 Department of Psychology, The University of Chicago, Chicago, IL, USA

* To whom correspondence should be addressed. E-mail: bradley{at}uchicago.edu.

We report on our efforts to establish an animal model for the development and testing of cortical visual prostheses. One-hundred fifty two electrodes were implanted in the primary visual cortex of a rhesus monkey. The electrodes were made from iridium with an activated iridium oxide film, which has a large charge capacity for a given surface area, and insulated with Parylene-C. One-hundred fourteen electrodes were functional after implantation. The activity of small (2-3) neuronal clusters was first recorded to map the visually responsive region corresponding to each electrode. The animal was then trained in a memory (delayed) saccade task, first with a visual target, then to a target defined by direct cortical stimulation with coordinates specified by the stimulating electrode's mapped receptive field. The standard deviation of saccade endpoints was ~2.5 larger for electrically stimulated vs visual saccades; nevertheless, when trial-to-trial scatter was averaged out, the correlation between saccade endpoints and receptive field locations was highly significant and approached unity after several months of training. Five electrodes were left unused until the monkey was fully trained; when these were introduced, the receptive field-saccade correlations were high on the first day of use (R=0.85, p=0.03 for angle, R=0.98, p<0.001 for eccentricity), indicating that the monkey had not learned to perform the task empirically by memorizing reward zones. The results of this experiment suggest the potential for rigorous behavioral testing of cortical visual prostheses in the macaque.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
M. Yoshida, K. Takaura, R. Kato, T. Ikeda, and T. Isa
Striate Cortical Lesions Affect Deliberate Decision and Control of Saccade: Implication for Blindsight
J. Neurosci., October 15, 2008; 28(42): 10517 - 10530.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. Kawasaki and D. L. Sheinberg
Learning to Recognize Visual Objects With Microstimulation in Inferior Temporal Cortex
J Neurophysiol, July 1, 2008; 100(1): 197 - 211.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. K. Elsley, B. Nagy, S. L. Cushing, and B. D. Corneil
Widespread Presaccadic Recruitment of Neck Muscles by Stimulation of the Primate Frontal Eye Fields
J Neurophysiol, September 1, 2007; 98(3): 1333 - 1354.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. J. Tehovnik and W. M. Slocum
What Delay Fields Tell Us About Striate Cortex
J Neurophysiol, August 1, 2007; 98(2): 559 - 576.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Z. Yang, D. J. Heeger, and E. Seidemann
Rapid and Precise Retinotopic Mapping of the Visual Cortex Obtained by Voltage-Sensitive Dye Imaging in the Behaving Monkey
J Neurophysiol, August 1, 2007; 98(2): 1002 - 1014.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. S. Pezaris and R. C. Reid
Demonstration of artificial visual percepts generated through thalamic microstimulation
PNAS, May 1, 2007; 104(18): 7670 - 7675.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
U. J. Ilg and S. Schumann
Primate Area MST-l Is Involved in the Generation of Goal-Directed Eye and Hand Movements
J Neurophysiol, January 1, 2007; 97(1): 761 - 771.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. J. Tehovnik, A. S. Tolias, F. Sultan, W. M. Slocum, and N. K. Logothetis
Direct and Indirect Activation of Cortical Neurons by Electrical Microstimulation
J Neurophysiol, August 1, 2006; 96(2): 512 - 521.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. R. Bartlett, E. A. DeYoe, R. W. Doty, B. B. Lee, J. D. Lewine, N. Negrao, and W. H. Overman Jr
Psychophysics of Electrical Stimulation of Striate Cortex in Macaques
J Neurophysiol, November 1, 2005; 94(5): 3430 - 3442.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. A. DeYoe, J. D. Lewine, and R. W. Doty
Laminar Variation in Threshold for Detection of Electrical Excitation of Striate Cortex by Macaques
J Neurophysiol, November 1, 2005; 94(5): 3443 - 3450.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2004 by the The American Physiological Society.