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J Neurophysiol (March 28, 2007). doi:10.1152/jn.01217.2006
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Submitted on November 18, 2006
Accepted on March 27, 2007

Layer- and cell type-specific effects of neonatal whisker-trimming in adult rat barrel cortex

Soo-Hyun Lee1, Peter W Land2, and Daniel J. Simons3*

1 Department of Neurobiology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, United States
2 Department of Neurobiology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, United States; Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
3 Department of Neurobiology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, United States; Department of Neurobiology, Univ Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States; Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

* To whom correspondence should be addressed. E-mail: cortex{at}pitt.edu.

Tactile deprivation in rats produced by whisker-trimming early in life leads to abnormally robust responses of excitatory neurons in layer 4 of primary somatosensory cortex when the re-grown whiskers are stimulated. Present findings from fast-spike neurons indicate that presumed inhibitory cells fire less robustly under the same conditions. These contrasting effects may reflect altered patterns of thalamocortical input to excitatory vs. inhibitory cells and/or changes in the strength of intracortical connections. Despite increased excitability of layer 4, neurons in layer 2/3 respond at control levels, even after full whisker re-growth. Layer 4 synapses onto supragranular neurons may be permanently depressed as a result of neonatal sensory deprivation.




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