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J Neurophysiol (March 28, 2007). doi:10.1152/jn.01228.2006
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01228.2006v1
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Submitted on November 22, 2006
Accepted on March 20, 2007

Persistent Synaptic Activity Produces Long-Lasting Enhancement of Endocannabinoid Modulation and Alters Long-Term Synaptic Plasticity

Ping Jun Zhu1 and David M Lovinger1*

1 Lab for Integrative Neuroscience, NIH/NIAAA, Bethesda, Maryland, United States

* To whom correspondence should be addressed. E-mail: lovindav{at}mail.nih.gov.

Learning and memory are thought to involve activity-dependent changes in synaptic efficacy such as long-term potentiation (LTP) and long-term depression (LTD). Recent studies indicate that endocannabinoid-dependent modulation of inhibitory transmission facilitates induction of hippocampal LTP and that endocannabinoids play a key role in certain forms of LTD. Here, we demonstrate that repetitive low-frequency synaptic stimulation (LFS) produces persistent up-regulation of endocannabinoid signaling at hippocampal CA1 GABAergic synapses. This LFS also produces LTD of inhibitory synapses and facilitates LTP at excitatory, glutamatertgic synapses. These endocannabinoid-mediated plastic changes could contribute to information storage within the brain.




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