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J Neurophysiol (February 15, 2006). doi:10.1152/jn.01328.2005
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Submitted on December 16, 2005
Accepted on February 11, 2006

The Stimulus for Rapid Ocular Dominance Plasticity in Visual Cortex

Cynthia D. Rittenhouse1, Beth A. Siegler1, Courtney A. Voelker1, Harel Z. Shouval2, Michael A. Paradiso1, and Mark F. Bear3*

1 Neuroscience, Brown University, Providence, RI, USA
2 Physics, Brown University, Providence, RI, USA
3 Neuroscience, Brown University, Providence, RI, USA; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, USA

* To whom correspondence should be addressed. E-mail: mbear{at}mit.edu.

Although it has been known for decades that monocular deprivation shifts ocular dominance in kitten striate cortex, uncertainty persists about the adequate stimulus for deprivation-induced losses of cortical responsiveness. In the current study we compared the effects of two days of lid closure and two days of monocular blur using an overcorrecting contact lens. Our finding of comparable ocular dominance shifts in visual cortex indicates that deprived-eye response depression is not a result of reduced retinal illumination. The quality rather than the quantity of retinal illumination is the key factor for ocular dominance plasticity. These data have implications for both the mechanism and treatment of amblyopia.




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