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J Neurophysiol (May 24, 2006). doi:10.1152/jn.01368.2005
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Submitted on December 24, 2005
Accepted on May 20, 2006

A Comparison of Effector-Specific Signals in Frontal and Parietal Cortices

Bonnie M Lawrence1* and Lawrence H Snyder2

1 Department of Psychology, Case Western Reserve University, Cleveland, Ohio, United States
2 Department of Anatomy and Neurobiology, Washington University School of Medicine, ST LOUIS, Missouri, United States

* To whom correspondence should be addressed. E-mail: bml15{at}case.edu.

We have previously demonstrated that the activities of neurons in the lateral intraparietal area (LIP) and the parietal reach region (PRR) of posterior parietal cortex (PPC) are modulated by non-spatial effector-specific information. We now report similar modulation in FEF, an area of frontal cortex that is reciprocally connected with LIP. While it is possible that these effector-specific signals originate in LIP and are conveyed to FEF, it is also possible that these signals originate in FEF and are "fed back" to LIP. We found that signal magnitude was no larger, and onset time no earlier, in FEF compared to LIP. Moreover, effector-specific activity in FEF, but not in LIP, was largely driven by spatial prediction. These results suggest that the saccade-related effector-specific signals found in LIP do not originate in FEF. Conversely, LIP may contribute to the effector-specific signals found in FEF, but does not wholly account for them.




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