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J Neurophysiol (July 2, 2008). doi:10.1152/jn.01377.2007
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01377.2007v1
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Submitted on December 20, 2007
Accepted on June 30, 2008

Modulation of phasic and tonic muscle synergies with reaching direction and speed

Andrea d'Avella1*, Laure Fernandez2, Alessandro Portone3, and Francesco Lacquaniti4

1 Department of Neuromotor Physiology, Santa Lucia Foundation, Rome, RM, Italy
2 Department of Neuromotor Physiology, Santa Lucia Foundation, Rome, RM, Italy; Institute of Movement Sciences, University of Mediterranean, Marseille, France
3 Department of Neuromotor Physiology, Santa Lucia Foundation, Rome, RM, Italy; Department of Neuroscience, University of Rome Tor Vergata, Rome, RM, Italy
4 Department of Neuromotor Physiology, Santa Lucia Foundation, Rome, RM, Italy; Department of Neuroscience, University of Rome Tor Vergata, Rome, RM, Italy; Center of Space Biomedicine, University of Rome Tor Vergata, Rome, RM, Italy

* To whom correspondence should be addressed. E-mail: a.davella{at}hsantalucia.it.

How the central nervous system (CNS) masters the many degrees-of-freedom of the musculoskeletal system to control goal-directed movements is a long standing question. We have recently provided support to the hypothesis that the CNS relies on a modular control architecture by showing that the phasic muscle patterns for fast reaching movements in different directions are generated by the combinations of a few time-varying muscle synergies —coordinated recruitment of groups of muscles with specific activation profiles. However, natural reaching movements occur at different speeds and require the control of both movement and posture. Thus, we have investigated whether muscle synergies also underlie reaching at different speeds as well as the maintenance of stable arm postures. Hand kinematics and shoulder and elbow muscles surface EMGs were recorded in five subjects during reaches to 8 targets in the frontal plane at different speeds. We found that the amplitude modulation of three time-invariant synergies captured the variations in the postural muscle patterns at the end of the movement. During movement, three phasic and three tonic time-varying synergies could reconstruct the time-normalized muscle pattern in all conditions. Phasic synergies were modulated in both amplitude and timing by direction and speed. Tonic synergies were only modulated in amplitude by direction. The directional tuning of both types of synergies was well described by a single or a double cosine function. These results suggest that muscle synergies are basic control modules that allow generating the appropriate muscle patterns through simple modulation and combination rules.







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Copyright © 2008 by the The American Physiological Society.