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J Neurophysiol 102: 1345-1347, 2009. First published July 1, 2009; doi:10.1152/jn.00356.2009
0022-3077/09 $8.00
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Is the Insula the "How Much" Intensity Coder?

Massieh Moayedi1,2 and Irit Weissman-Fogel2

1Institute of Medical Science, University of Toronto; and 2Department of Brain, Imaging and Behaviour, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada

Abstract

The perception of all sensations includes some sort of magnitude estimate used to calibrate behavior. However, it is not known whether unique intensity coding mechanisms exist for specific modalities or whether a common, centralized magnitude estimator operates for all sensations. Here, we discuss findings regarding pain intensity coding and the role of the insula in pain in light of the recent article by Baliki and colleagues that proposes the insula as a multimodal magnitude estimator.

Address for reprint requests and other correspondence: M. Moayedi, Institute of Medical Science, University of Toronto, 610 University Ave., Toronto, ON, Canada M5G 2M9 (E-mail: mmoayedi{at}uhnres.utoronto.ca)






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