HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 102/4/2009    most recent 00441.2009v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Lafourcade, C. A. PubMed PubMed Citation Articles by Lafourcade, C. A.

BRIEF-REPORT

Presynaptic Mechanisms of Endocannabinoid-Mediated Long-Term Depression in the Hippocampus

¹Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland; and ²Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

ABSTRACT

Endogenous cannabinoids (eCBs) mobilized from postsynaptic cells activate presynaptic cannabinoid receptors and thereby inhibit synaptic transmitter release. The inhibition can be either brief (seconds) or long-lasting (minutes to hours). Recent studies provide insight into the presynaptic mechanisms responsible for long-lasting, eCB-mediated long-term depression. Among these, the proteins PKA and RIM1 appear to be crucial, although other possibilities are emerging.