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J Neurophysiol (February 1, 2003). 10.1152/jn.00819.2002
Submitted on Submitted 19 April 2002; accepted in final form 23 October 2002
Neurology Department, Royal Prince Alfred Hospital, Sydney NSW 2050, Australia
Aw, S. T.,
M. J. Todd,
L. A. McGarvie,
A. A. Migliaccio, and
G. M. Halmagyi.
Effects of Unilateral Vestibular Deafferentation on the Linear
Vestibulo-Ocular Reflex Evoked by Impulsive Eccentric Roll
Rotation. J. Neurophysiol. 89: 969-978, 2003. The effects of unilateral vestibular deafferentation (UVD) on
the linear vestibulo-ocular reflex (LVOR) were studied by measuring three-dimensional eye movements in seven UVD subjects evoked by impulsive eccentric roll rotation while viewing an earth-fixed target
at 200, 300, or 600 mm and comparing their responses to 11 normal
subjects. The stimulus, a whole-body roll of approximately 1°, with
the eye positioned 815 mm eccentric to the rotation axis, produced an
inter-aural linear acceleration of approximately 0.5g and a
roll acceleration of approximately 360°/s2. The
responses generated by the LVOR comprise horizontal eye rotations.
Horizontal eye velocity at 100 ms from stimulus onset in UVD subjects
was significantly lower than in normal subjects for all viewing
distances, with no significant difference between ipsilesional and
contralesional responses. LVOR acceleration gain, defined as the slope
of actual horizontal eye velocity divided by the slope of ideal
horizontal eye velocity during a 30-ms period starting 70 ms from
stimulus onset, was bilaterally significantly reduced in UVD subjects
at all viewing distances. Acceleration gain from all viewing distances
was 1.04 ± 0.28 in normal subjects, and in UVD subjects was
0.49 ± 0.23 for ipsilesional and 0.63 ± 0.27 for
contralesional acceleration. LVOR enhancement in the first 100 ms by
near viewing was still present in UVD subjects. LVOR latency in UVD
subjects (approximately 39 ms) was not significantly different from
normal subjects (approximately 36 ms). After UVD, LVOR is bilaterally
and largely symmetrically reduced, but latency remains unchanged and
modulation by viewing distance is still present.
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