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J Neurophysiol (May 1, 2003). 10.1152/jn.01042.2002
Submitted on Submitted 19 November 2002; accepted in final form 16 January 2003
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6058
Dhingra, Narender K.,
Yen-Hong Kao,
Peter Sterling, and
Robert
G. Smith.
Contrast Threshold of a Brisk-Transient Ganglion Cell In Vitro. J. Neurophysiol. 89: 2360-2369, 2003. We measured the contrast threshold for mammalian brisk-transient
ganglion cells in vitro. Spikes were recorded extracellularly in the
intact retina (guinea pig) in response to a spot with sharp onset,
flashed for 100 ms over the receptive field center. Probability density
functions were constructed from spike responses to stimulus contrasts
that bracketed threshold. Then an "ideal observer" (IO) compared
additional trials to these probability distributions and decided, using
a single-interval, two-alternative forced-choice procedure, which
contrasts had most likely been presented. From these decisions we
constructed neurometric functions that yielded the threshold contrast
by linear interpolation. Based on the number of spikes in a response,
the IO detected contrasts as low as 1% [4.2 ± 0.4% (SE);
n = 35]; based on the temporal pattern of spikes, the
IO detected contrasts as low as 0.8% (2.8 ± 0.2%). Contrast increments above a very low "basal contrast" were discriminated with greater sensitivity than they were detected against the
background. Performance was optimal near 37°C and declined with a
Q10 of about 2, similar to that of
retinal metabolism. By the method used by previous in vivo studies of
brisk-transient cells, our most sensitive cells had similar thresholds.
The in vitro measurements thus provide an important benchmark for
comparing sensitivity of neurons upstream (cone and bipolar cell) and
downstream to assess efficiency of retinal and central circuits.
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