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J Neurophysiol 89: 2441-2448, 2003. First published January 22, 2003; doi:10.1152/jn.01139.2002
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J Neurophysiol (May 1, 2003). 10.1152/jn.01139.2002
Submitted on Submitted 18 December 2002; accepted in final form 20 January 2003

Chemical Response Pattern of Different Classes of C-Nociceptors to Pruritogens and Algogens

M. Schmelz,1,4 R. Schmidt,2 C. Weidner,1 Marita Hilliges,3 H. E. Torebjörk,2 and H. O. Handwerker1

 1Department of Physiology and Experimental Pathophysiology, University of Erlangen/Nuremberg, D-91054 Erlangen, Germany;  2Department of Clinical Neurophysiology, University of Uppsala, S-75185 Uppsala, Sweden;  3Department of Basic Oral Sciences, Karolinska Institute, S-14104 Huddinge, Sweden;  4Department of Anesthesiology, Medical Faculty Mannheim, University of Heidelberg, 61087 Mannheim, Germany

Schmelz, M., R. Schmidt, C. Weidner, Marita Hilliges, H. E. Torebjörk, and H. O. Handwerker. Chemical Response Pattern of Different Classes of C-Nociceptors to Pruritogens and Algogens. J. Neurophysiol. 89: 2441-2448, 2003. Vasoneuroactive substances were applied through intradermal microdialysis membranes and characterized as itch- or pain-inducing in psychophysical experiments. Histamine always provoked itching and rarely pain, capsaicin always pain but never itching. Prostaglandin E2 (PGE2) led preferentially to moderate itching. Serotonin, acetylcholine, and bradykinin induced pain more often than itching. Subsequently the same substances were used in microneurography experiments to characterize the sensitivity profile of human cutaneous C-nociceptors. The responses of 89 mechanoresponsive (CMH, polymodal nociceptors), 52 mechanoinsensitive, histamine-negative (CMiHis-), and 24 mechanoinsensitive, histamine-positive (CMiHis+) units were compared. CMiHis+ units were most responsive to histamine and to PGE2 and less to serotonin, ACh, bradykinin, and capsaicin. CMH units (polymodal nociceptors) and CMiHis- units showed significantly weaker responses to histamine, PGE2, and acetylcholine. Capsaicin and bradykinin responses were not significantly different in the two classes of mechano-insensitive units. We conclude that CMiHis+ units are "selective," but not "specific" for pruritogenic substances and that the pruritic potency of a mediator increases with its ability to activate CMiHis+ units but decreases with activation of CMH and CMiHis- units.




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