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Department of Neurology, University of Chicago, Chicago, Illinois 60615
Submitted 27 January 2003; accepted in final form 26 February 2003
The spike-time reliability of motoneurons in the Aplysia buccal
motor ganglion was studied as a function of the frequency content and the
relative amplitude of the fluctuations in the neuronal input, calculated as
the coefficient of variation (CV). Measurements of spike-time reliability to
sinusoidal and aperiodic inputs, as well as simulations of a noisy leaky
integrate-and-fire neuron stimulated by spike trains drawn from a periodically
modulated process, demonstrate that there are three qualitatively different
CV-dependent mechanisms that determine reliability: noise-dominated (CV <
0.05 for Aplysia motoneurons) where spike timing is unreliable
regardless of frequency content; resonance-dominated (CV 
0.05–0.25)
where reliability is reduced by removal of input frequencies equal to
motoneuron firing rate; and amplitude-dominated (CV >0.35) where
reliability depends on input frequencies greater than motoneuron firing rate.
In the resonance-dominated regime, changes in the activity of the presynaptic
inhibitory interneuron B4/5 alter motoneuron spike-time reliability. The
increases or decreases in reliability occur coincident with small changes in
motoneuron spiking rate due to changes in interneuron activity. Injection of a
hyperpolarizing current into the motoneuron reproduces the interneuron-induced
changes in reliability. The rate-dependent changes in reliability can be
understood from the phase-locking properties of regularly spiking motoneurons
to periodic inputs. Our observations demonstrate that the ability of a neuron
to support a spike-time code can be actively controlled by varying the
properties of the neuron and its input.
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