HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 90/2/599    most recent 01097.2002v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (18) Citing Articles via Google Scholar Google Scholar Articles by Weible, A. P. Articles by Disterhoft, J. F. Search for Related Content PubMed PubMed Citation Articles by Weible, A. P. Articles by Disterhoft, J. F.

Activity Profiles of Single Neurons in Caudal Anterior Cingulate Cortex During Trace Eyeblink Conditioning in the Rabbit

Department of Physiology and Institute for Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611

Submitted 6 December 2002; accepted in final form 8 May 2003

Acquisition of trace eyeblink conditioning involves the association of a conditioned stimulus (CS) with an unconditioned stimulus (US) separated by a stimulus-free trace interval. This form of conditioning is dependent upon the hippocampus and the caudal anterior cingulate cortex (AC), in addition to brain stem and cerebellar circuitry. Hippocampal involvement in trace eyeblink conditioning has been studied extensively, but the involvement of caudal AC is less well understood. In the present study, we compared neuronal responses from rabbits given either paired (trace conditioning) or unpaired (pseudoconditioning) presentations of the CS and US. Presentation of the CS elicited significant increases in neuronal activity at the onset of both trace conditioning and pseudoconditioning. A robust CS-elicited neuronal response persisted throughout the first 2 days of trace conditioning, declining gradually across subsequent training sessions. In contrast, the magnitude of the CS-elicited excitatory response during pseudoconditioning began to decline within the first 10 trials. Neurons exhibiting excitatory responses to the CS during trace conditioning also exhibited excitatory responses to the US that were significantly greater in magnitude than US-elicited responses during pseudoconditioning. CS-elicited decreases in neuronal activity became more robust over the course of trace conditioning compared to pseudoconditioning. Reductions in activity during the CS interval consistently preceded excitation in both training groups, suggesting that the CS-elicited decreases in neuronal activity may serve to increase the signal-to-noise ratio of the excitatory response to the tone. Taken together, these data suggest that the caudal AC is involved early in trace eyeblink conditioning and that maintenance of the CS-elicited excitatory response may serve to signal the salience of the tone.

This article has been cited by other articles:

				L. C. Flores and J. F. Disterhoft Caudate Nucleus Is Critically Involved in Trace Eyeblink Conditioning J. Neurosci., November 18, 2009; 29(46): 14511 - 14520. [Abstract] [Full Text] [PDF]

				A. P. Weible, D. C. Rowland, R. Pang, and C. Kentros Neural Correlates of Novel Object and Novel Location Recognition Behavior in the Mouse Anterior Cingulate Cortex J Neurophysiol, October 1, 2009; 102(4): 2055 - 2068. [Abstract] [Full Text] [PDF]

				B. E. Kalmbach, T. Ohyama, J. C. Kreider, F. Riusech, and M. D. Mauk Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioning Learn. Mem., January 7, 2009; 16(1): 86 - 95. [Abstract] [Full Text] [PDF]

				C. K. Young and N. McNaughton Coupling of Theta Oscillations between Anterior and Posterior Midline Cortex and with the Hippocampus in Freely Behaving Rats Cereb Cortex, January 1, 2009; 19(1): 24 - 40. [Abstract] [Full Text] [PDF]

				M. J. Miller, C. Weiss, X. Song, G. Iordanescu, J. F. Disterhoft, and A. M. Wyrwicz Functional Magnetic Resonance Imaging of Delay and Trace Eyeblink Conditioning in the Primary Visual Cortex of the Rabbit J. Neurosci., May 7, 2008; 28(19): 4974 - 4981. [Abstract] [Full Text] [PDF]

				R. Leal-Campanario, A. Fairen, J. M. Delgado-Garcia, and A. Gruart Electrical stimulation of the rostral medial prefrontal cortex in rabbits inhibits the expression of conditioned eyelid responses but not their acquisition PNAS, July 3, 2007; 104(27): 11459 - 11464. [Abstract] [Full Text] [PDF]

				A. Gruart, C. Sciarretta, M. Valenzuela-Harrington, J. M. Delgado-Garcia, and L. Minichiello Mutation at the TrkB PLC{gamma}-docking site affects hippocampal LTP and associative learning in conscious mice Learn. Mem., January 1, 2007; 14(1-2): 54 - 62. [Abstract] [Full Text] [PDF]

				R. Galvez, C. Weiss, A. P. Weible, and J. F. Disterhoft Vibrissa-signaled eyeblink conditioning induces somatosensory cortical plasticity. J. Neurosci., May 31, 2006; 26(22): 6062 - 6068. [Abstract] [Full Text] [PDF]

				K. Takehara-Nishiuchi, S. Kawahara, and Y. Kirino NMDA receptor-dependent processes in the medial prefrontal cortex are important for acquisition and the early stage of consolidation during trace, but not delay eyeblink conditioning Learn. Mem., November 1, 2005; 12(6): 606 - 614. [Abstract] [Full Text] [PDF]

				A. L. Griffin and S. D. Berry Inactivation of the Anterior Cingulate Cortex Impairs Extinction of Rabbit Jaw Movement Conditioning and Prevents Extinction-Related Inhibition of Hippocampal Activity Learn. Mem., September 1, 2004; 11(5): 604 - 610. [Abstract] [Full Text] [PDF]