HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 90/3/1842    most recent 00065.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Pluto, C. P. Articles by Rhoades, R. W. Search for Related Content PubMed PubMed Citation Articles by Pluto, C. P. Articles by Rhoades, R. W.

Role of Development in Reorganization of the SI Forelimb-Stump Representation in Fetally, Neonatally, and Adult Amputated Rats

Department of Anatomy and Neurobiology, Medical College of Ohio, Toledo, Ohio 43614

Submitted 24 January 2003; accepted in final form 27 May 2003

Rats that sustain forelimb removal on postnatal day (P) 0 exhibit numerous multi-unit recording sites in the forelimb-stump representation of primary somatosensory cortex (SI) that also respond to hindlimb stimulation when cortical GABA_A+B receptors are blocked. Most of these hindlimb inputs originate in the medial SI hindlimb representation. Although many forelimb-stump sites in these animals respond to hindlimb stimulation, very few respond to stimulation of the face (vibrissae or lower jaw), which is represented in SI just lateral to the forelimb. The lateral to medial development of SI may influence the capacity of hindlimb (but not face) inputs to "invade" the forelimb-stump region in neonatal amputees. The SI forelimb-stump was mapped in adult (>60 days) rats that had sustained amputation on embryonic day (E) 16, on P0, or during adulthood. GABA receptors were blocked and subsequent mapping revealed increases in nonstump inputs in E16 and P0 amputees: fetal amputees exhibited forelimb-stump sites responsive to face (34%), hindlimb (10%), and both (22%); neonatal amputees exhibited 10% face, 39% hindlimb, and 5% both; adult amputees exhibited 10% face, 5% hindlimb, and 0% both, with 80% stump-only sites. These results indicate age-dependent differences in receptive-field reorganization of the forelimb-stump representation, which may reflect the spatiotemporal development of SI. Results from cobalt chloride inactivation of the SI vibrissae region and electrolesioning of the dysgranular cortex suggest that normally suppressed vibrissae inputs to the SI forelimb-stump area originate in the SI vibrissae region and synapse in the dysgranular cortex.

This article has been cited by other articles:

				R. D. Lane, C. P. Pluto, C. L. Kenmuir, N. L. Chiaia, and R. D. Mooney Does Reorganization in the Cuneate Nucleus Following Neonatal Forelimb Amputation Influence Development of Anomalous Circuits Within the Somatosensory Cortex? J Neurophysiol, February 1, 2008; 99(2): 866 - 875. [Abstract] [Full Text] [PDF]

				T. A. Woolsey Should One Hand (Paw) Really Not Know What the Other Is Doing? Focus on "Reducing Contralateral SI Activity Reveals Hindlimb Receptive Fields in the SI Forelimb-Stump Representation of Neonatally Amputated Rats" J Neurophysiol, September 1, 2005; 94(3): 1666 - 1667. [Full Text] [PDF]

				C. P. Pluto, R. D. Lane, and R. W. Rhoades Local GABA Receptor Blockade Reveals Hindlimb Responses in the SI Forelimb-Stump Representation of Neonatally Amputated Rats J Neurophysiol, July 1, 2004; 92(1): 372 - 379. [Abstract] [Full Text] [PDF]