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J Neurophysiol 90: 2171-2179, 2003. First published June 18, 2003; doi:10.1152/jn.01177.2002
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Watermaze Learning Enhances Excitability of CA1 Pyramidal Neurons

M. Matthew Oh*, Amy G. Kuo*, Wendy W. Wu, Evgeny A. Sametsky and John F. Disterhoft

Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611

Submitted 30 December 2002; accepted in final form 12 June 2003

The dorsal hippocampus is crucial for learning the hidden-platform location in the hippocampus-dependent, spatial watermaze task. We have previously demonstrated that the postburst afterhyperpolarization (AHP) of hippocampal pyramidal neurons is reduced after acquisition of the hippocampus-dependent, temporal trace eyeblink conditioning task. We report here that the AHP and one or more of its associated currents (IAHP and/or sIAHP) are reduced in dorsal hippocampal CA1 pyramidal neurons from rats that learned the watermaze task as compared with neurons from control rats. This reduction was a learning-induced phenomenon as the AHP of CA1 neurons from rats that failed to learn the hidden-platform location was similar to that of neurons from control rats. We propose that reduction of the AHP in pyramidal neurons in regions crucial for learning is a cellular mechanism of learning that is conserved across species and tasks.

Address for reprint requests and other correspondence: M. M. Oh or A. G. Kuo, Dept. of Physiology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Ave., Chicago, IL 60611 (E-mail: mattoh{at}northwestern.edu or a-gamelli{at}northwestern.edu).




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