JN Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 90: 2720-2730, 2003. First published July 2, 2003; doi:10.1152/jn.00370.2003
0022-3077/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
90/4/2720    most recent
00370.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Luther, J. A.
Right arrow Articles by Golowasch, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Luther, J. A.
Right arrow Articles by Golowasch, J.

Episodic Bouts of Activity Accompany Recovery of Rhythmic Output By a Neuromodulator- and Activity-Deprived Adult Neural Network

Jason A. Luther1, Alice A. Robie1, John Yarotsky2, Christopher Reina2, Eve Marder1 and Jorge Golowasch3

1 Volen Center, Brandeis University, Waltham, Massachusetts 02454 2 Federated Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102 3 Department of Mathematical Sciences and Federated Department of Biological Sciences, New Jersey Institute of Technology, Newark, New Jersey 07102

Submitted 14 April 2003; accepted in final form 27 June 2003

The pyloric rhythm of the stomatogastric ganglion of the crab, Cancer borealis, slows or stops when descending modulatory inputs are acutely removed. However, the rhythm spontaneously resumes after one or more days in the absence of neuromodulatory input. We recorded continuously for days to characterize quantitatively this recovery process. Activity bouts lasting 40–900 s began several hours after removal of neuromodulatory input and were followed by stable rhythm recovery after 1–4 days. Bout duration was not related to the intervals (0.3–800 min) between bouts. During an individual bout, the frequency rapidly increased and then decreased more slowly. Photoablation of back-filled neuromodulatory terminals in the stomatogastric ganglion (STG) neuropil had no effect on activity bouts or recovery, suggesting that these processes are intrinsic to the STG neuronal network. After removal of neuromodulatory input, the phase relationships of the components of the triphasic pyloric rhythm were altered, and then over time the phase relationships moved toward their control values. Although at low pyloric rhythm frequency the phase relationships among pyloric network neurons depended on frequency, the changes in frequency during recovery did not completely account for the change in phase seen after rhythm recovery. We suggest that activity bouts represent underlying mechanisms controlling the restructuring of the pyloric network to allow resumption of an appropriate output after removal of neuromodulatory input.

Address for reprint requests and other correspondence: E. Marder, Volen Center, MS 013, Brandeis University, 415 South St., Waltham, MA 02454-9110 (E-mail: marder{at}brandeis.edu).




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
A. Sakurai and P. S. Katz
Functional Recovery after Lesion of a Central Pattern Generator
J. Neurosci., October 21, 2009; 29(42): 13115 - 13125.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Zhang, O. Khorkova, R. Rodriguez, and J. Golowaschi
Activity and Neuromodulatory Input Contribute to the Recovery of Rhythmic Output After Decentralization in a Central Pattern Generator
J Neurophysiol, January 1, 2009; 101(1): 372 - 386.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. J. Rehm, A. L. Taylor, S. R. Pulver, and E. Marder
Spectral Analyses Reveal the Presence of Adult-Like Activity in the Embryonic Stomatogastric Motor Patterns of the Lobster, Homarus americanus
J Neurophysiol, June 1, 2008; 99(6): 3104 - 3122.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
O. Khorkova and J. Golowasch
Neuromodulators, Not Activity, Control Coordinated Expression of Ionic Currents
J. Neurosci., August 8, 2007; 27(32): 8709 - 8718.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. L. Howard, A. Neu, R. J. Morgan, J. C. Echegoyen, and I. Soltesz
Opposing Modifications in Intrinsic Currents and Synaptic Inputs in Post-Traumatic Mossy Cells: Evidence for Single-Cell Homeostasis in a Hyperexcitable Network
J Neurophysiol, March 1, 2007; 97(3): 2394 - 2409.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. J. Haedo and J. Golowasch
Ionic Mechanism Underlying Recovery of Rhythmic Activity in Adult Isolated Neurons
J Neurophysiol, October 1, 2006; 96(4): 1860 - 1876.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Bucher, A. L. Taylor, and E. Marder
Central Pattern Generating Neurons Simultaneously Express Fast and Slow Rhythmic Activities in the Stomatogastric Ganglion
J Neurophysiol, June 1, 2006; 95(6): 3617 - 3632.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Bucher, A. A. Prinz, and E. Marder
Animal-to-Animal Variability in Motor Pattern Production in Adults and during Growth
J. Neurosci., February 16, 2005; 25(7): 1611 - 1619.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the The American Physiological Society.