| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454; 2Instituto de Neurociencias, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas, 03550 San Juan de Alicante, Spain; 3Section of Neurobiology, Yale School of Medicine, New Haven, Connecticut 06520; 4Stockholm Bioinformatic Center, SCFAB, S-10691 Stockholm; and 5Computational Biology, Department of Physics, Linköpings Institute of Technology, S-581 83 Linköping, Sweden
Submitted 23 October 2002; accepted in final form 21 May 2003
An important question in neuroscience is whether and how temporal patterns and fluctuations in neuronal spike trains contribute to information processing in the cortex. We have addressed this issue in the memory-related circuits of the prefrontal cortex by analyzing spike trains from a database of 229 neurons recorded in the dorsolateral prefrontal cortex of 4 macaque monkeys during the performance of an oculomotor delayed-response task. For each task epoch, we have estimated their power spectrum together with interspike interval histograms and autocorrelograms. We find that 1) the properties of most (about 60%) neurons approximated the characteristics of a Poisson process. For about 25% of cells, with characteristics typical of interneurons, the power spectrum showed a trough at low frequencies (<20 Hz) and the autocorrelogram a dip near zero time lag. About 15% of neurons had a peak at <20 Hz in the power spectrum, associated with the burstiness of the spike train; 2) a small but significant task dependency of spike-train temporal structure: delay responses to preferred locations were characterized not only by elevated firing, but also by suppressed power at low (<20 Hz) frequencies; and 3) the variability of interspike intervals is typically higher during the mnemonic delay period than during the fixation period, regardless of the remembered cue. The high irregularity of neural persistent activity during the delay period is likely to be a characteristic signature of recurrent prefrontal network dynamics underlying working memory.
This article has been cited by other articles:
|
|
 |
|
  A. Compte, R. Reig, V. F. Descalzo, M. A. Harvey, G. D. Puccini, and M. V. Sanchez-Vives Spontaneous High-Frequency (10-80 Hz) Oscillations during Up States in the Cerebral Cortex In Vitro J. Neurosci., December 17, 2008; 28(51): 13828 - 13844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Roxin, V. Hakim, and N. Brunel The Statistics of Repeating Patterns of Cortical Activity Can Be Reproduced by a Model Network of Stochastic Binary Neurons J. Neurosci., October 15, 2008; 28(42): 10734 - 10745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Thurley, W. Senn, and H.-R. Luscher Dopamine Increases the Gain of the Input-Output Response of Rat Prefrontal Pyramidal Neurons J Neurophysiol, June 1, 2008; 99(6): 2985 - 2997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Carter and X.-J. Wang Cannabinoid-Mediated Disinhibition and Working Memory: Dynamical Interplay of Multiple Feedback Mechanisms in a Continuous Attractor Model of Prefrontal Cortex Cereb Cortex, September 1, 2007; 17(suppl_1): i16 - i26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Durstewitz and T. Gabriel Dynamical Basis of Irregular Spiking in NMDA-Driven Prefrontal Cortex Neurons Cereb Cortex, April 1, 2007; 17(4): 894 - 908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zaksas and T. Pasternak Directional Signals in the Prefrontal Cortex and in Area MT during a Working Memory for Visual Motion Task. J. Neurosci., November 8, 2006; 26(45): 11726 - 11742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Soltani and X.-J. Wang A biophysically based neural model of matching law behavior: melioration by stochastic synapses. J. Neurosci., April 5, 2006; 26(14): 3731 - 3744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pavlova, N. Birbaumer, and A. Sokolov Attentional Modulation of Cortical Neuromagnetic Gamma Response to Biological Movement Cereb Cortex, March 1, 2006; 16(3): 321 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Miller and X.-J. Wang Power-Law Neuronal Fluctuations in a Recurrent Network Model of Parametric Working Memory J Neurophysiol, February 1, 2006; 95(2): 1099 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Homayoun and B. Moghaddam Bursting of Prefrontal Cortex Neurons in Awake Rats is Regulated by Metabotropic Glutamate 5 (mGlu5) Receptors: Rate-dependent Influence and Interaction with NMDA Receptors Cereb Cortex, January 1, 2006; 16(1): 93 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gonzalez-Burgos, S. Kroener, J. K. Seamans, D. A. Lewis, and G. Barrionuevo Dopaminergic Modulation of Short-Term Synaptic Plasticity in Fast-Spiking Interneurons of Primate Dorsolateral Prefrontal Cortex J Neurophysiol, December 1, 2005; 94(6): 4168 - 4177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Homayoun, M. E. Jackson, and B. Moghaddam Activation of Metabotropic Glutamate 2/3 Receptors Reverses the Effects of NMDA Receptor Hypofunction on Prefrontal Cortex Unit Activity in Awake Rats J Neurophysiol, April 1, 2005; 93(4): 1989 - 2001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gonzalez-Burgos, L. S. Krimer, N. V. Povysheva, G. Barrionuevo, and D. A. Lewis Functional Properties of Fast Spiking Interneurons and Their Synaptic Connections With Pyramidal Cells in Primate Dorsolateral Prefrontal Cortex J Neurophysiol, February 1, 2005; 93(2): 942 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Gulledge and G. J. Stuart Action Potential Initiation and Propagation in Layer 5 Pyramidal Neurons of the Rat Prefrontal Cortex: Absence of Dopamine Modulation J. Neurosci., December 10, 2003; 23(36): 11363 - 11372. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
