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J Neurophysiol (September 24, 2008). doi:10.1152/jn.90238.2008
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Submitted on February 6, 2008
Revised on September 15, 2008
Accepted on September 16, 2008

Control of predictive error correction during a saccadic double-step task

K. M. Sharika1, Arjun Ramakrishnan1, and Aditya Murthy1*

1 National Brain Research Centre

* To whom correspondence should be addressed. E-mail: aditya{at}nbrc.ac.in.

We explored the nature of control during error correction using a modified double-step saccadic task in which subjects cancelled the initial saccade to the first target and redirected gaze to a second target. Failure to inhibit was associated with a quick corrective saccade suggesting that errors and corrections may be planned concurrently. However, since saccade programming constitutes a visual and a motor stage of preparation, the extent to which parallel processing occurs in anticipation of the error is not known. To estimate the time course of error correction, a triple-step condition was introduced that displaced the second target during the error. In these trials, corrective saccades directed at the location of the target prior to the third step suggest motor preparation of the corrective saccade in parallel with the error. To estimate the time course of motor preparation of the corrective saccade we used an accumulator model (LATER) to fit the reaction times to the triple-step stimuli; the best-fit data revealed that the onset of correction could occur even before the start of the error. The estimated start of motor correction was also observed to be delayed as target step delay decreased, suggesting a form of interference between concurrent motor programmes. Taken together we interpret these results to indicate that predictive error correction may occur concurrently while the oculomotor system is trying to inhibit an unwanted movement and suggest a model of how inhibitory control and error correction may coordinate to enable goal directed behaviors.







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