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J Neurophysiol (July 16, 2008). doi:10.1152/jn.90613.2008
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Submitted on May 27, 2008
Revised on July 9, 2008
Accepted on July 9, 2008

Effect of synaptic connectivity on long-range synchronization of fast cortical oscillations

Maxim Bazhenov1*, Nikolai F Rulkov2, and Igor Timofeev3

1 University of California, Riverside
2 UCSD
3 Laval University

* To whom correspondence should be addressed. E-mail: Maksim.Bazhenov{at}ucr.edu.

Cortical gamma oscillations in the 20-80 Hz range are associated with attentiveness and sensory perception and have strong connections to both cognitive processing and temporal binding of sensory stimuli. These gamma oscillations become synchronized within a few milliseconds over distances spanning a few millimeters in spite of synaptic delays. In this study using in vivo re-cordings and large-scale cortical network models, we reveal a critical role played by the network geometry in achieving precise long-range synchronization in the gamma frequency band. Our results indicate that the presence of many independent synaptic pathways in a two-dimensional network facilitate precise phase synchronization of fast gamma band oscillations with nearly zero phase delays between remote network sites. These findings predict a common mechanism of pre-cise oscillatory synchronization in neuronal networks.







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