Submitted on June 17, 2008
Revised on July 5, 2008
Accepted on July 23, 2008
Large-Scale Chronically Implantable Precision Motorized Microdrive Array for Freely Behaving Animals
Jun Yamamoto1* and Matthew A Wilson1
1 MIT
* To whom correspondence should be addressed. E-mail: yamajun{at}mit.edu.
Multiple single-unit recording has become one of the most powerful in vivo electro-physiological techniques for investigating neural circuits. The demand has been increasing for small and lightweight chronic recording devices that allow fine adjustments to be made over large numbers of electrodes across multiple brain regions. To achieve this, we developed precision motorized microdrive arrays that use a novel motor multiplexing headstage to dramatically reduce wiring while preserving precision of the microdrive control. Versions of the microdrive array were chronically implanted on both rats (21 microdrives) and mice (7 microdrives) and relatively long term recordings were taken.
