JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 91: 555-560, 2004. First published September 10, 2003; doi:10.1152/jn.00694.2003
0022-3077/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
91/1/555    most recent
00694.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ninokura, Y.
Right arrow Articles by Tanji, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ninokura, Y.
Right arrow Articles by Tanji, J.

Report

Integration of Temporal Order and Object Information in the Monkey Lateral Prefrontal Cortex

Yoshihisa Ninokura1,2, Hajime Mushiake1,2 and Jun Tanji1,2

1Department of Physiology, Tohoku University School of Medicine, Sendai 980, Japan; and 2CORE Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kawaguchi 332, Japan

Submitted 18 July 2003; accepted in final form 9 September 2003

Generation of information about the temporal order of events is essential for the control of memory-based behavioral tasks. We studied cellular activity in the lateral prefrontal cortex (LPFC) in two monkeys that were required to remember the temporal order in which visual objects were presented. In this report, we focus on cellular activity in response to the sequential appearance of three different objects. We identified cells that responded selectively to physical properties (color and shape) of objects (23%) in the ventral part of the LPFC and cells for which activity was selective for the numerical position (rank order) of objects (44%) in the dorsal part of the LPFC. We also identified cells for which activity was selective for both the physical properties and rank order of objects (30%). The third type of cells, distributed in the ventral LPFC, seems of importance in integrating the two categories of information, i.e., physical and temporal information about the occurrences of objects to construct sequential order information. Furthermore, we identified a distinct group of cells that exhibited selectivity for the sequence of presentation of the three objects. Our findings suggest that LPFC cells are involved in encoding temporal sequences of events when such information is required for planning forthcoming motor behavior.

Address for reprint requests and other correspondence: J. Tanji, Dept. of Physiology, Tohoku University School of Medicine, Sendai 980, Japan (E-mail: tanjij{at}mail.cc.tohoku.ac.jp).




This article has been cited by other articles:


Home page
 Schizophr BullHome page
J. D. Ragland, R. Cools, M. Frank, D. A. Pizzagalli, A. Preston, C. Ranganath, and A. D. Wagner
CNTRICS Final Task Selection: Long-Term Memory
Schizophr Bull, October 16, 2008; (2008) sbn134v1.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. Tanji and E. Hoshi
Role of the Lateral Prefrontal Cortex in Executive Behavioral Control
Physiol Rev, January 1, 2008; 88(1): 37 - 57.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Amiez and M. Petrides
Selective involvement of the mid-dorsolateral prefrontal cortex in the coding of the serial order of visual stimuli in working memory
PNAS, August 21, 2007; 104(34): 13786 - 13791.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Botvinick and T. Watanabe
From Numerosity to Ordinal Rank: A Gain-Field Model of Serial Order Representation in Cortical Working Memory
J. Neurosci., August 8, 2007; 27(32): 8636 - 8642.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. Durstewitz and T. Gabriel
Dynamical Basis of Irregular Spiking in NMDA-Driven Prefrontal Cortex Neurons
Cereb Cortex, April 1, 2007; 17(4): 894 - 908.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. Nieder, I. Diester, and O. Tudusciuc
Temporal and spatial enumeration processes in the primate parietal cortex.
Science, September 8, 2006; 313(5792): 1431 - 1435.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Genovesio, P. J. Brasted, and S. P. Wise
Representation of future and previous spatial goals by separate neural populations in prefrontal cortex.
J. Neurosci., July 5, 2006; 26(27): 7305 - 7316.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
T. Orlov, D. J. Amit, V. Yakovlev, E. Zohary, and S. Hochstein
Memory of ordinal number categories in macaque monkeys.
J. Cogn. Neurosci., March 1, 2006; 18(3): 399 - 417.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Inoue and A. Mikami
Prefrontal Activity During Serial Probe Reproduction Task: Encoding, Mnemonic, and Retrieval Processes
J Neurophysiol, February 1, 2006; 95(2): 1008 - 1041.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Hoshi, H. Sawamura, and J. Tanji
Neurons in the Rostral Cingulate Motor Area Monitor Multiple Phases of Visuomotor Behavior With Modest Parametric Selectivity
J Neurophysiol, July 1, 2005; 94(1): 640 - 656.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
A. Nieder and E. K. Miller
Analog Numerical Representations in Rhesus Monkeys: Evidence for Parallel Processing
J. Cogn. Neurosci., June 1, 2004; 16(5): 889 - 901.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Hoshi and J. Tanji
Area-Selective Neuronal Activity in the Dorsolateral Prefrontal Cortex for Information Retrieval and Action Planning
J Neurophysiol, June 1, 2004; 91(6): 2707 - 2722.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the The American Physiological Society.