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J Neurophysiol (October 1, 2008). doi:10.1152/jn.91037.2008
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Submitted on September 16, 2008
Revised on September 28, 2008
Accepted on September 29, 2008

What can population calcium imaging tell us about neural circuits?

Alex C Kwan1*

1 Cornell University

* To whom correspondence should be addressed. E-mail: cak46{at}cornell.edu.

Calcium imaging of bulk-loaded fluorescent indicators can be used to record the spiking activity of hundreds of neurons. Recent advances promise imaging technologies that are faster, more efficient, and applicable to awake animals, thereby moving imaging capabilities closer to the traditional strengths of multi-electrode arrays. This article reviews these technical achievements and discusses how they can help us achieve the goal of understanding neural circuits.






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