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J Neurophysiol (April 8, 2009). doi:10.1152/jn.91254.2008
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Submitted on November 17, 2008
Revised on March 30, 2009
Accepted on April 1, 2009

Direction and contrast tuning of macaque MSTd neurons during saccades

Nathan A Crowder1*, Nicholas SC Price2, Michael J Mustari3, and Michael R Ibbotson4

1 Dalhousie University
2 Harvard
3 Yerkes National Primate Research Center
4 Australian National university

* To whom correspondence should be addressed. E-mail: nathan.crowder{at}dal.ca.

Saccades are rapid eye movements that change the direction of gaze, however the full-field image motion associated with these movements is rarely perceived. The attenuation of visual perception during saccades is referred to as saccadic suppression. The mechanisms that produce saccadic suppression are not well understood. We recorded from neurons in the dorsal medial superior temporal area (MSTd) of alert macaque monkeys and compared the neural responses produced by the retinal slip associated with saccades (active motion) to responses evoked by identical motion presented during fixation (passive motion). We provide evidence for a neural correlate of saccadic suppression and expand on two contentious results from previous studies. First, we confirm the finding that some neurons in MSTd reverse their preferred direction during saccades. We quantify this effect by calculating changes in direction tuning index for a large cell population. Second, it has been noted that neural activity associated with saccades can arrive in the parietal cortex up to 30 ms earlier than activity produced by similar visual stimulation during fixation. This led to the question of whether the saccade related responses were visual in origin, or were motor signals arising from saccade-planning areas of the brain. By comparing the responses to saccades made over textured backgrounds of different contrasts, we provide strong evidence that saccade related responses were visual in origin. Refinements of the possible models of saccadic suppression are discussed.







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