HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 92/3/1558    most recent 00300.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (19) Citing Articles via Google Scholar Google Scholar Articles by Karakossian, M. H. Articles by Otis, T. S. Search for Related Content PubMed PubMed Citation Articles by Karakossian, M. H. Articles by Otis, T. S.

Excitation of Cerebellar Interneurons by Group I Metabotropic Glutamate Receptors

Department of Neurobiology, University of California Medical Center, Los Angeles, California 90095-1763

Submitted 25 March 2004; accepted in final form 11 May 2004

Cerebellar basket and stellate neurons (BSNs) provide feed-forward inhibition to Purkinje neurons (PNs) and thereby play a principal role in determining the output of the cerebellar cortex. During low-frequency transmission, glutamate released at parallel fiber synapses excites BSNs by binding to AMPA receptors; high-frequency transmission also recruits N-methyl-D-aspartate (NMDA) receptors. We find that, in addition to these ligand-gated receptors, a G-protein–coupled glutamate receptor subtype participates in exciting BSNs. Stimulation of metabotropic glutamate receptor 1 (mGluR1) with the mGluR agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) leads to an increase in spontaneous firing of BSNs and indirectly to an increase in the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) recorded in PNs. Under conditions in which ligand-gated glutamate receptors are blocked, parallel fiber stimulation generates a slow excitatory postsynaptic current (EPSC) in BSNs that is inhibited by mGluR1-selective antagonists. This slow EPSC is capable of increasing BSN spiking and indirectly increasing sIPSCs frequency in PNs. Our findings reinforce the idea that distinct subtypes of glutamate receptors are activated in response to different patterns of activity at excitatory synapses. The results also raise the possibility that mGluR1-dependent forms of synaptic plasticity may occur at excitatory inputs to BSNs.

This article has been cited by other articles:

				T. Collin, R. Franconville, B. E. Ehrlich, and I. Llano Activation of Metabotropic Glutamate Receptors Induces Periodic Burst Firing and Concomitant Cytosolic Ca2+ Oscillations in Cerebellar Interneurons J. Neurosci., July 22, 2009; 29(29): 9281 - 9291. [Abstract] [Full Text] [PDF]

				F. Ferraguti, L. Crepaldi, and F. Nicoletti Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives Pharmacol. Rev., December 1, 2008; 60(4): 536 - 581. [Abstract] [Full Text] [PDF]

				B. Rossi, G. Maton, and T. Collin Calcium-permeable presynaptic AMPA receptors in cerebellar molecular layer interneurones J. Physiol., November 1, 2008; 586(21): 5129 - 5145. [Abstract] [Full Text] [PDF]

				I. C. Duguid, Y. Pankratov, G. W. J. Moss, and T. G. Smart Somatodendritic Release of Glutamate Regulates Synaptic Inhibition in Cerebellar Purkinje Cells via Autocrine mGluR1 Activation J. Neurosci., November 14, 2007; 27(46): 12464 - 12474. [Abstract] [Full Text] [PDF]

				F. Crepel and H. Daniel Developmental Changes in Agonist-Induced Retrograde Signaling at Parallel Fiber Purkinje Cell Synapses: Role of Calcium-Induced Calcium Release J Neurophysiol, November 1, 2007; 98(5): 2550 - 2565. [Abstract] [Full Text] [PDF]

				R. Piet and C. E. Jahr Glutamatergic and Purinergic Receptor-Mediated Calcium Transients in Bergmann Glial Cells J. Neurosci., April 11, 2007; 27(15): 4027 - 4035. [Abstract] [Full Text] [PDF]

				M. Beierlein and W. G. Regehr Local Interneurons Regulate Synaptic Strength by Retrograde Release of Endocannabinoids J. Neurosci., September 27, 2006; 26(39): 9935 - 9943. [Abstract] [Full Text] [PDF]

				M. Beierlein and W. G. Regehr Brief bursts of parallel fiber activity trigger calcium signals in bergmann glia. J. Neurosci., June 28, 2006; 26(26): 6958 - 6967. [Abstract] [Full Text] [PDF]

				A. Rancillac, J. Rossier, M. Guille, X.-K. Tong, H. Geoffroy, C. Amatore, S. Arbault, E. Hamel, and B. Cauli Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. J. Neurosci., June 28, 2006; 26(26): 6997 - 7006. [Abstract] [Full Text] [PDF]

				M. Ennis, M. Zhu, T. Heinbockel, and A. Hayar Olfactory Nerve-Evoked, Metabotropic Glutamate Receptor-Mediated Synaptic Responses in Rat Olfactory Bulb Mitral Cells J Neurophysiol, April 1, 2006; 95(4): 2233 - 2241. [Abstract] [Full Text] [PDF]

				M. Hirono and K. Obata {alpha}-Adrenoceptive Dual Modulation of Inhibitory GABAergic Inputs to Purkinje Cells in the Mouse Cerebellum J Neurophysiol, February 1, 2006; 95(2): 700 - 708. [Abstract] [Full Text] [PDF]