JN Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 92: 2113-2121, 2004. First published April 21, 2004; doi:10.1152/jn.00266.2004
0022-3077/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
92/4/2113    most recent
00266.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (23)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liao, D. S.
Right arrow Articles by Ramoa, A. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liao, D. S.
Right arrow Articles by Ramoa, A. S.

Recovery of Cortical Binocularity and Orientation Selectivity After the Critical Period for Ocular Dominance Plasticity

David S. Liao1, Thomas E. Krahe1, Glen T. Prusky2, Alexandre E. Medina1 and Ary S. Ramoa1

1Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298-0709; and 2Department of Psychology and Neuroscience, The University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada

Submitted 18 March 2004; accepted in final form 15 April 2004

Cortical binocularity is abolished by monocular deprivation (MD) during a critical period of development lasting from approximately postnatal day (P) 35 to P70 in ferrets. Although this is one of the best-characterized models of neural plasticity and amblyopia, very few studies have examined the requirements for recovery of cortical binocularity and orientation selectivity of deprived eye responses. Recent studies indicating that different mechanisms regulate loss and recovery of binocularity raise the possibility that different sensitive periods characterize loss and recovery of deprived eye responses. In this report, we have examined whether the potential for recovery of binocularity and orientation selectivity is restricted to the critical period. Quantitative single unit recordings revealed recovery of cortical binocularity and full recovery of orientation selectivity of deprived eye responses following prolonged periods of MD (i.e., >3 wk) starting at P49, near the peak of plasticity. Surprisingly, recovery was present when binocular vision was restored after the end of the critical period for ocular dominance plasticity, as late as P83. In contrast, ferrets that had never received visual experience through the deprived eye failed to recover binocularity even though normal binocular vision was restored at P50, halfway through the critical period. Collectively, these results indicate that there is potential for recovery of cortical binocularity and deprived eye orientation selectivity after the end of the critical period for ocular dominance plasticity.

Address for reprint requests and other correspondence: A. S. Ramoa, Dept. of Anatomy and Neurobiology, Virginia Commonwealth Univ. School of Medicine, 1101 E. Marshall St., Sanger Hall Rm. 12-042, Richmond VA 23298-0709 (E-mail: asramoa{at}vcu.edu).




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. Di Marco, V. A. Nguyen, S. Bisti, and D. A. Protti
Permanent Functional Reorganization of Retinal Circuits Induced by Early Long-Term Visual Deprivation
J. Neurosci., October 28, 2009; 29(43): 13691 - 13701.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. J. Wallace and B. Sakmann
Plasticity of Representational Maps in Somatosensory Cortex Observed by In Vivo Voltage-Sensitive Dye Imaging
Cereb Cortex, June 1, 2008; 18(6): 1361 - 1373.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Pizzorusso, P. Medini, S. Landi, S. Baldini, N. Berardi, and L. Maffei
Structural and functional recovery from early monocular deprivation in adult rats
PNAS, May 30, 2006; 103(22): 8517 - 8522.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Sakai, H. Bi, I. Maruko, B. Zhang, J. Zheng, J. Wensveen, R. S. Harwerth, E. L. Smith III, and Y. M. Chino
Cortical Effects of Brief Daily Periods of Unrestricted Vision During Early Monocular Form Deprivation
J Neurophysiol, May 1, 2006; 95(5): 2856 - 2865.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. D. Faulkner, V. Vorobyov, and F. Sengpiel
Visual Cortical Recovery From Reverse Occlusion Depends on Concordant Binocular Experience
J Neurophysiol, March 1, 2006; 95(3): 1718 - 1726.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R. W. Li, K. G. Young, P. Hoenig, and D. M. Levi
Perceptual Learning Improves Visual Performance in Juvenile Amblyopia
Invest. Ophthalmol. Vis. Sci., September 1, 2005; 46(9): 3161 - 3168.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. M. Chalupa
Complete Restoration of Visual Cortical Responses is Possible Late in Development. Focus on "Recovery of Cortical Binocularity and Orientation Selectivity After the Critical Period for Ocular Dominance Plasticity"
J Neurophysiol, October 1, 2004; 92(4): 1969 - 1970.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the The American Physiological Society.