| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Department of Integrative Physiology, National Institute for Physiological Sciences and 2Department of Physiological Sciences, Graduate University for Advanced Studies, Myodaiji, Okazaki, Aichi, Japan; and 3Graduate School of Frontier Biosciences, Osaka University, Toyonaka, Osaka, Japan
Submitted 28 May 2004; accepted in final form 23 August 2004
To examine the role of competitive and cooperative neural interactions within the intermediate layer of superior colliculus (SC), we elevated the basal SC neuronal activity by locally injecting a cholinergic agonist nicotine and analyzed its effects on saccade performance. After microinjection, spontaneous saccades were directed toward the movement field of neurons at the injection site (affected area). For visually guided saccades, reaction times were decreased when targets were presented close to the affected area. However, when visual targets were presented remote from the affected area, reaction times were not increased regardless of the rostrocaudal level of the injection sites. The endpoints of visually guided saccades were biased toward the affected area when targets were presented close to the affected area. After this endpoint effect diminished, the trajectories of visually guided saccades remained modestly curved toward the affected area. Compared with the effects on endpoints, the effects on reaction times were more localized to the targets close to the affected area. These results are consistent with a model that saccades are triggered by the activities of neurons within a restricted region, and the endpoints and trajectories of the saccades are determined by the widespread population activity in the SC. However, because increased reaction times were not observed for saccades toward targets remote from the affected area, inhibitory interactions in the SC may not be strong enough to shape the spatial distribution of the low-frequency preparatory activities in the SC.
This article has been cited by other articles:
|
|
 |
|
  T. Isa and W. C. Hall Exploring the Superior Colliculus In Vitro J Neurophysiol, November 1, 2009; 102(5): 2581 - 2593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sooksawate, K. Isa, and T. Isa Cholinergic Responses in Crossed Tecto-Reticular Neurons of Rat Superior Colliculus J Neurophysiol, November 1, 2008; 100(5): 2702 - 2711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yoshida, K. Takaura, R. Kato, T. Ikeda, and T. Isa Striate Cortical Lesions Affect Deliberate Decision and Control of Saccade: Implication for Blindsight J. Neurosci., October 15, 2008; 28(42): 10517 - 10530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Hemelt and A. Keller Superior Colliculus Control of Vibrissa Movements J Neurophysiol, September 1, 2008; 100(3): 1245 - 1254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Liu and M. A. Basso Substantia Nigra Stimulation Influences Monkey Superior Colliculus Neuronal Activity Bilaterally J Neurophysiol, August 1, 2008; 100(2): 1098 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. McPeek Reversal of a Distractor Effect on Saccade Target Selection After Superior Colliculus Inactivation J Neurophysiol, May 1, 2008; 99(5): 2694 - 2702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Dorris, E. Olivier, and D. P. Munoz Competitive Integration of Visual and Preparatory Signals in the Superior Colliculus during Saccadic Programming J. Neurosci., May 9, 2007; 27(19): 5053 - 5062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. Mrsic-Flogel, S. B. Hofer, C. Creutzfeldt, I. Cloez-Tayarani, J.-P. Changeux, T. Bonhoeffer, and M. Hubener Altered Map of Visual Space in the Superior Colliculus of Mice Lacking Early Retinal Waves J. Neurosci., July 20, 2005; 25(29): 6921 - 6928. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
