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Spatial Overlap of ON and OFF Subregions and Its Relation to Response Modulation Ratio in Macaque Primary Visual Cortex

¹Department of Neurobiology, David Geffen School of Medicine; and ²Departments of Neurobiology and Psychology, Biomedical Engineering Interdepartmental Program, Brain Research Institute, Jules Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California

Submitted 2 July 2004; accepted in final form 8 September 2004

We studied the spatial overlap of ON and OFF subregions in macaque primary visual cortex and its relation to the response modulation ratio (the F₁/F₀ ratio). Spatial maps of ON and OFF subregions were obtained by reverse correlation with a dynamic noise pattern of bright and dark spots. Two spatial maps, ON and OFF, were produced by cross-correlating the spike train with the location of bright and dark spots in the stimulus respectively. Several measures were used to assess the degree of overlap between subregions. In a subset of neurons, we also computed the F₁/F₀ ratio in response to drifting sinusoidal gratings. Significant correlations were found among all the overlap measures and the F₁/F₀ ratio. Most overlap indices considered, and the F₁/F₀ measure, had bimodal distributions. In contrast, the distance between on and off subregions normalized by their size was unimodal. Surprisingly, a simple model that additively combines ON and OFF subregions with spatial separations drawn from a unimodal distribution, can readily explain the data. These analyses clarify the relationship between subregion overlap and the F₁/F₀ ratio in macaque primary visual cortex, and a simple model provides a parsimonious explanation for the co-existence of bimodal distributions of overlap indices and a unimodal distribution of the normalized distance.

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