JN Miami Valley Hospital
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 93: 1598-1610, 2005. First published November 10, 2004; doi:10.1152/jn.00843.2004
0022-3077/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
93/3/1598    most recent
00843.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (25)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kröner, S.
Right arrow Articles by Barrionuevo, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kröner, S.
Right arrow Articles by Barrionuevo, G.

Dopamine Modulates Excitability of Basolateral Amygdala Neurons In Vitro

Sven Kröner1,3,*, J. Amiel Rosenkranz1,*, Anthony A. Grace1,2 and German Barrionuevo1,3

1Departments of Neuroscience and 2Psychiatry and Psychology, University of Pittsburgh; and 3Center for Neural Basis of Cognition, Pittsburgh, Pennsylvania

Submitted 17 August 2004; accepted in final form 3 November 2004

The amygdala plays a role in affective behaviors, which are modulated by the dopamine (DA) innervation of the basolateral amygdala complex (BLA). Although in vivo studies indicate that activation of DA receptors alters BLA neuronal activity, it is unclear whether DA exerts direct effects on BLA neurons or whether it acts via indirect effects on BLA afferents. Using whole cell patch-clamp recordings in rat brain slices, we investigated the site and mechanisms through which DA regulates the excitability of BLA neurons. Dopamine enhanced the excitability of BLA projection neurons in response to somatic current injections via a postsynaptic effect. Dopamine D1 receptor activation increased excitability and evoked firing, whereas D2 receptor activation increased input resistance. Current- and voltage-clamp experiments in projection neurons showed that D1 receptor activation enhanced excitability by modulating a 4-aminopyridine- and {alpha}-dendrotoxin-sensitive, slowly inactivating K+ current. Furthermore, DA and D1 receptor activation increased evoked firing in fast-spiking BLA interneurons. Consistent with a postsynaptic modulation of interneuron excitability, DA also increased the frequency of spontaneous inhibitory postsynaptic currents recorded in projection neurons without changing release of GABA. These data demonstrate that DA exerts direct effects on BLA projection neurons and indirect actions via modulation of interneurons that may work in concert to enhance the neuronal response to large, suprathreshold inputs, while suppressing weaker inputs.

Present address and address for reprint requests and other correspondence: S. Kröner, Dept. of Physiology, Medical University of South Carolina, 173 Ashley Ave., 403 BSB, Charleston, SC 29425 (E-mail: kroener{at}musc.edu)




This article has been cited by other articles:


Home page
 Cereb CortexHome page
H. Trantham-Davidson, S. Kroner, and J. K. Seamans
Dopamine Modulation of Prefrontal Cortex Interneurons Occurs Independently of DARPP-32
Cereb Cortex, April 1, 2008; 18(4): 951 - 958.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. M. Power and P. Sah
Competition between Calcium-Activated K+ Channels Determines Cholinergic Action on Firing Properties of Basolateral Amygdala Projection Neurons
J. Neurosci., March 19, 2008; 28(12): 3209 - 3220.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Yamamoto, Y. Ueta, and N. Kato
Dopamine Induces a Slow Afterdepolarization in Lateral Amygdala Neurons
J Neurophysiol, August 1, 2007; 98(2): 984 - 992.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
S. R. Laviolette
Dopamine Modulation of Emotional Processing in Cortical and Subcortical Neural Circuits: Evidence for a Final Common Pathway in Schizophrenia?
Schizophr Bull, July 1, 2007; 33(4): 971 - 981.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Kroner, L. S. Krimer, D. A. Lewis, and G. Barrionuevo
Dopamine Increases Inhibition in the Monkey Dorsolateral Prefrontal Cortex through Cell Type-Specific Modulation of Interneurons
Cereb Cortex, May 1, 2007; 17(5): 1020 - 1032.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. A. Rosenkranz and D. Johnston
Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex.
J. Neurosci., March 22, 2006; 26(12): 3229 - 3244.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
R. T. LaLumiere and J. L. McGaugh
Memory enhancement induced by post-training intrabasolateral amygdala infusions of {beta}-adrenergic or muscarinic agonists requires activation of dopamine receptors: Involvement of right, but not left, basolateral amygdala
Learn. Mem., September 1, 2005; 12(5): 527 - 532.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the The American Physiological Society.