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J Neurophysiol 93: 1816-1819, 2005. First published September 29, 2004; doi:10.1152/jn.00672.2004
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Dopamine D1-Receptors Modulate Lateral Inhibition Between Principal Cells of the Nucleus Accumbens

Stefano Taverna1,2, Barbara Canciani2 and Cyriel M. A. Pennartz1,3

1Graduate School Neurosciences Amsterdam; 2Department of Anatomy, Vrije Universiteit Medical Center, Amsterdam; and 3Department of Animal Physiology and Cognitive Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands

Submitted 2 July 2004; accepted in final form 23 September 2004

One of the current hypotheses on dopamine in the physiology of motivation posits that this neurotransmitter regulates filtering and selection of inputs to the nucleus accumbens. The effects of dopamine (100 µM) and the D1-receptor agonist SKF 38393 (20–50 µM) on GABAergic synaptic transmission between pairs of principal cells of rat nucleus accumbens were studied by using simultaneous dual patch-clamp recordings in acutely prepared brain slices. Both compounds attenuated postsynaptic responses induced by presynaptic firing and this effect was reversed by the D1-receptor antagonist SCH 23390 (25 µM). This attenuating effect of dopamine D1-receptors may act to diminish competitive interactions between single projection neurons or ensembles in the nucleus accumbens.

Address for reprint requests and other correspondence: C.M.A. Pennartz, University of Amsterdam, Swammerdam Institute for Life Sciences, Department of Animal Physiology and Cognitive Neuroscience, Kruislaan 320, 1090 GB Amsterdam, The Netherlands (E-mail: pennartz{at}science.uva.nl)




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