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INNOVATIVE METHODOLOGY

Spatial Reconstruction of Trajectories of an Array of Recording Microelectrodes

¹Brain Sciences Center, Veterans Affairs Medical Center, Minneapolis; ²Departments of Neuroscience, ³Neurology, and ⁴Psychiatry, University of Minnesota Medical School, and ⁵Cognitive Sciences Center, University of Minnesota, Minneapolis, Minnesota

Submitted 7 June 2004; accepted in final form 4 November 2004

We present a method for estimating the locations of sites visited by an array of microelectrodes. The method relies on visualization of tracks made by electrodes coated in a fluorescent dye. These tracks are used to estimate the parameters of a simple geometrical model that generates coordinates for each recording site. We describe several ways to measure the error of this procedure and present experimental results from recordings in the motor cortex of macaque monkeys that suggest that errors are of the order of 230 µm. We also introduce a coordinate transformation that takes into account the convoluted structure of the cortex near sulci to conveniently visualize recording site locations in a rectilinear representation. This method greatly extends the capabilities of microelectrodes for studying the three-dimensional structure of topographic maps in the cortex.

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